Chemistry of Natural Compounds

The international scientific journal Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.

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Additional research articles see Current Chemistry Research Articles. Magazines with similar content (chemistry of natural producrs and compounds):

 - Amino Acids.

 - Biomacromolecules.

 - BMC Structural Biology.

 - Journal of Natural Products.

 - Molecules.

 - Natural Product Reports.

Chemical Composition and Cytotoxic Activity of Daphne glomerate and D. pontica

Bioactive Compounds from the Antarctic Bacterium Pseudomonas SP. A6-5

Composition of Volatiles of the Essential Oil from the Leaves of Carpinus betulus

A New Triterpene from Metadina trichotoma

One new triterpene, 6α-hydroxyilexosapogenin A (1), and nine known compounds were isolated from Metadina trichotoma. Their structures were mainly elucidated by NMR and MS spectra. As evidenced by a glucose concentration assay, compound 2 can stimulate glucose uptake in 3T3-L1 adipocytes and is the first pyrocincholic acid type triterpenoid that shows promoting glucose uptake activity.

Phenolic Acids Isolated from the Leaves of Gynura procumbens and their Nitric Oxide Production Inhibitory Activities

Chemical Constituents of the Leaves of Abutilon hirtum and Their Antimicrobial Activity

Chemical Constituents of Clematis huchouensis

Two New Sesquiterpenes from the Stems of Fissistigma maclurei

Two new sesquiterpenes, 7-hydroxy-15-nor-α-cadin-4-one (1) and 15-nor-α-cadin-4-one (2), together with six known sesquiterpenes (3–8), were isolated from the stems of Fissistigma maclurei Merr. Their structures were elucidated using comprehensive spectroscopic methods. All compounds were evaluated on their anti-inflammatory activities via testing the inhibitory activities against nitric oxide (NO) production induced by lipopolysaccharides in mouse macrophage RAW 264.7 cells in vitro.

Secondary Metabolites from Bacillus thuringiensis HS66

A New Stilbenoid from Caryopteris incana

A new stilbenoid, methyl 2,4-dihydroxy-6-(4-hydroxyphenethyl)-3-methylbenzoate (1), along with 11 known compounds, cirsimaritin (2), cirsiliol (3), quercetin (4), apigenin (5), acacetin (6), genkwanin (7), luteolin (8), caffeic acid (9), esculetin (10), alternariol (11), and alternariol-5-O-methyl ether (12), was isolated from the 70% EtOH extract of Caryopteris incana. The structures of these compounds were established via extensive spectroscopic techniques, including 1D, 2D NMR, and HR-ESI-MS. Compound 1 exhibited moderate cytotoxic activity against human HepG2 and SMMC-7721 hepatoma cell lines with IC₅₀ values of 21.3 and 20.1 μM, respectively.

New Metabolite from the Fungus Monascus lunisporas BCRC 33640

Careful examination of the hexane-soluble fraction of the ethanolic extract of red mold rice fermented with the yellow mutant of the fungus Monascus lunisporas BCRC 33640 (Eurotiaceae) led to the isolation of a new sesquiterpenoid derivative, namely monasuslunin (1) together with nine known compounds (2–10). Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HR-ESI-MS analyses.

A New Diphenyl Derivative from Endogenous Phoma sp. Associated with the Edible Mushroom Boletus edulis

An endogenous fungus was isolated from the edible mushroom Boletus edulis and determined as Phoma sp. The metabolites from Phoma sp. NM-46 were investigated. A new diphenyl derivative and two known phytotoxins were found from Phoma sp. NM-46, and their structures were determined by 1D NMR, 2D NMR, and HR-ESI-MS. The phytotoxins (2, 3) indicated obvious antifungal activities against phytopathogens, Epicoccum sorghinum, Colletotrichum gloeosporioides, and Nigrospora oryzae with MICs of 8–64 μg/mL.

Antinociceptive Diterpenoid Alkaloids from the Roots of Aconitum pseudostapfianum

Phytochemical investigation of the roots of Aconitum pseudostapfianum resulted in the isolation of two new C19-diterpenoid alkaloids, designated as pseudostapines A and B (1 and 2). Their structures were determined by spectral methods such as 1D and 2D (¹H–¹H COSY, HMQC, NOESY, and HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry. The isolated alkaloids were tested in vivo for antinociceptive potential. The results show that pseudostapines A and B possess more potent antinociceptive effect than the positive control drugs aspirin and acetaminophen.

Comparative Characteristics of Carotenoid Profiles and Antiradical Properties of Extracts of Brown Kelp from the Sea of Japan

Alkaloids from the Leaves and Twigs of Bousigonia angustifolia

Chemical Constituents of the Leaves and Twigs of Flueggea virosa

A New Chromone from Roots of Saposhnikovia divaricata

One new chromone, (2′S,4′S)-5′-hydroxy-5-O-methylvisamminol (1), was isolated from the roots of Saposhnikovia divaricata. The structure of compound 1 was identified by spectroscopic methods including 1D, 2D NMR, and HR-ESI-MS data. The absolute configuration of compound 1 was elucidated by electronic circular dichroism (ECD) calculation. Compound 1 showed moderate cytotoxic activity against human prostatic cancer PC-3 and breast cancer MCF-7 cell lines, with IC₅₀ values of 52.66 ± 1.73 and 83.12 ± 8.50 μM, respectively.

Isolation and Characterization of Hepatoprotective Xanthones from the Fruits of Hovenia acerba

Hovenia acerba Lindl. is not only a delicious fruit but also a traditional Chinese medicine because of its nutritional and medicinal value. A new xanthone, named 1,3-dihydroxy-2-geranyl-4-isoprenyl-5-prenyl-11,12-dimethylpyranoxanthen-10-one (1), and six known xanthones 2–7 were isolated from H. acerba Lindl. for the first time. Compounds 1–7 were assayed for their hepatoprotective activities in HepG2 cells with bicyclol as the positive control. Among them, compounds 1, 3, and 4 showed moderate hepatoprotective activities in improving HepG2 cell survival rates from 52.74 ± 1.37% (APAP, 10 mM) to 73.14 ± 3.31%, 66.26 ± 4.97%, and 61.70 ± 6.43%, respectively.

Index of Natural Objects

New Metabolite from the Fungus Monascus argentinensis BCRC 33998

Phytochemical investigation of the CH₂Cl₂-soluble fraction of the EtOH extract of red mold rice fermented with the white mutant of the fungus Monascus argentinensis BCRC 33998 (Eurotiaceae) led to the isolation and characterization of a new diterpenoid, monascusargentinoic acid (1). The structure of the new compound was elucidated by analysis of its spectroscopic data, including MS, 1D, and 2D NMR experiments, and comparison with literature data of known compounds.

Category: Current Chemistry Research

Last update: 28.03.2018.

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