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Journal of Medicinal Chemistry

Current research reports and chronological list of recent articles..




The international scientific Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

To search this web page for specific words type "Ctrl" + "F" on your keyboard (Command + "F" on a Mac). Then: type the word you are searching for in the window that pops up!

Additional research articles see Current Chemistry Research Articles. Magazines with similar content (medicinal chemistry):

 - Bioorganic and Medicinal Chemistry Letters,

 - European Journal of Medicinal Chemistry,

 - Journal of Enzyme Inhibition and Medicinal Chemistry,

 - Medicinal Chemistry Research.



Journal of Medicinal Chemistry - Abstracts



[ASAP] Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00779

Datum: 20.09.2019


[ASAP] Structure–Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00898

Datum: 20.09.2019


[ASAP] Discovery of Pyrrolo[2,3-<italic toggle="yes">b</italic>]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-<italic toggle="yes">Trypanosoma cruzi</italic> Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01275

Datum: 20.09.2019


[ASAP] Structure–Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from <italic toggle="yes">Schistosoma mansoni</italic> (<italic toggle="yes">Sm</italic>Sirt2)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00638

Datum: 20.09.2019


[ASAP] Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00995

Datum: 18.09.2019


[ASAP] Designing around Structural Alerts in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00917

Datum: 17.09.2019


[ASAP] Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00445

Datum: 17.09.2019


[ASAP] Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-ß-Lactamases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00911

Datum: 16.09.2019


[ASAP] Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00847

Datum: 16.09.2019


[ASAP] Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01094

Datum: 16.09.2019


[ASAP] Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00763

Datum: 16.09.2019


[ASAP] Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00410

Datum: 13.09.2019


[ASAP] Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00728

Datum: 13.09.2019


[ASAP] Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00565

Datum: 13.09.2019


[ASAP] Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00963

Datum: 12.09.2019


[ASAP] A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00972

Datum: 11.09.2019


[ASAP] Antioxidant-Conjugated 1,2,4-Triazolo[4,3-<italic toggle="yes">a</italic>]pyrazin-3-one Derivatives: Highly Potent and Selective Human A<sub>2A</sub> Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00778

Datum: 10.09.2019


[ASAP] Expression of Concern for “Identification of Eukaryotic Translation Elongation Factor 1-a 1 Gamendazole-Binding Site for Binding of 3-Hydroxy-4(1<italic toggle="yes">H</italic>)-quinolinones as Novel Ligands with Anticancer Activity”

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01384

Datum: 09.09.2019


[ASAP] Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01003

Datum: 09.09.2019


[ASAP] Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00753

Datum: 06.09.2019


[ASAP] Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00946

Datum: 04.09.2019


[ASAP] 2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01112

Datum: 04.09.2019


[ASAP] Machine Learning Models for Accurate Prediction of Kinase Inhibitors with Different Binding Modes

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00867

Datum: 30.08.2019


[ASAP] Synthesis and Evaluation of Novel TLR2 Agonists as Potential Adjuvants for Cancer Vaccines

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01044

Datum: 30.08.2019


[ASAP] Structure Defines Function: Clinically Relevant Mutations in ErbB Kinases<subtitle>Miniperspective</subtitle>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00964

Datum: 28.08.2019


[ASAP] Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00959

Datum: 27.08.2019


[ASAP] Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00924

Datum: 27.08.2019


[ASAP] Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00446

Datum: 26.08.2019


[ASAP] New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation<subtitle>Miniperspective</subtitle>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00885

Datum: 22.08.2019


[ASAP] Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00875

Datum: 20.08.2019


[ASAP] The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00761

Datum: 20.08.2019


[ASAP] How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using <italic toggle="yes">N</italic>-Myristoyltransferases as a Model System

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00586

Datum: 19.08.2019


[ASAP] Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00716

Datum: 19.08.2019


[ASAP] Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00855

Datum: 15.08.2019


[ASAP] Developing and Characterization of Chemically Modified RNA Aptamers for Targeting Wild Type and Mutated c-KIT Receptor Tyrosine Kinases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00868

Datum: 15.08.2019


[ASAP] Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00683

Datum: 15.08.2019


[ASAP] Discovery of 4-Methylquinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00969

Datum: 06.08.2019


[ASAP] Identification of Novel Medulloblastoma Cell-Targeting Peptides for Use in Selective Chemotherapy Drug Delivery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00851

Datum: 01.08.2019


[ASAP] Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00511

Datum: 01.08.2019


[ASAP] Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00522

Datum: 24.07.2019


[ASAP] Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00797

Datum: 18.07.2019


[ASAP] Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00444

Datum: 18.07.2019


[ASAP] Identification of <italic toggle="yes">N</italic>-Methyl Nicotinamide and <italic toggle="yes">N</italic>-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00443

Datum: 17.07.2019


[ASAP] TASK Channels Pharmacology: New Challenges in Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00248

Datum: 15.07.2019


[ASAP] Bio-Inspired Dual-Selective <italic toggle="yes">BCL-2</italic>/<italic toggle="yes">c-MYC</italic> G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-<italic toggle="yes">i</italic>]purine Derivatives

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00262

Datum: 10.07.2019


[ASAP] In Silico Prediction of Hemolytic Toxicity on the Human Erythrocytes for Small Molecules by Machine-Learning and Genetic Algorithm

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00853

Datum: 08.07.2019


[ASAP] Norepinephrine-Transporter-Targeted and DNA-Co-Targeted Theranostic Guanidines

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00437

Datum: 03.07.2019


[ASAP] Why Some Targets Benefit from beyond Rule of Five Drugs

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b01732

Datum: 26.06.2019


[ASAP] Are We Opening the Door to a New Era of Medicinal Chemistry or Being Collapsed to a Chemical Singularity?<subtitle>Perspective</subtitle>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00004

Datum: 26.06.2019


[ASAP] Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00220

Datum: 25.06.2019


 


Category: Current Chemistry Research

Last update: 28.03.2018.






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