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Journal of Medicinal Chemistry

Current research reports and chronological list of recent articles..




The international scientific Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

To search this web page for specific words type "Ctrl" + "F" on your keyboard (Command + "F" on a Mac). Then: type the word you are searching for in the window that pops up!

Additional research articles see Current Chemistry Research Articles. Magazines with similar content (medicinal chemistry):

 - Bioorganic and Medicinal Chemistry Letters,

 - European Journal of Medicinal Chemistry,

 - Journal of Enzyme Inhibition and Medicinal Chemistry,

 - Medicinal Chemistry Research.



Journal of Medicinal Chemistry - Abstracts



[ASAP] Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00848

Datum: 20.10.2021


[ASAP] Chromosome Region Maintenance 1 (XPO1/CRM1) as an Anticancer Target and Discovery of Its Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01145

Datum: 20.10.2021


[ASAP] Gold(I) Bis(1,2,3-triazol-5-ylidene) Complexes as Promising Selective Anticancer Compounds

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01021

Datum: 20.10.2021


[ASAP] Discovery of Next-Generation Tropomyosin Receptor Kinase Inhibitors for Combating Multiple Resistance Associated with Protein Mutation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01539

Datum: 20.10.2021


[ASAP] Cell-Based Drug Discovery: Identification and Optimization of Small Molecules that Reduce <italic toggle="yes">c</italic>-MYC Protein Levels in Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01416

Datum: 20.10.2021


[ASAP] Interfering with the Tumor–Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01409

Datum: 20.10.2021


[ASAP] Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01076

Datum: 20.10.2021


[ASAP] Discovery of IHMT-EZH2-115 as a Potent and Selective Enhancer of Zeste Homolog 2 (EZH2) Inhibitor for the Treatment of B-Cell Lymphomas

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01154

Datum: 19.10.2021


[ASAP] Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01307

Datum: 19.10.2021


[ASAP] Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00994

Datum: 19.10.2021


[ASAP] Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01299

Datum: 18.10.2021


[ASAP] Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01579

Datum: 18.10.2021


[ASAP] Targeted Delivery and Site-Specific Activation of β-Cyclodextrin-Conjugated Photosensitizers for Photodynamic Therapy through a Supramolecular Bio-orthogonal Approach

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01505

Datum: 18.10.2021


[ASAP] A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01481

Datum: 18.10.2021


[ASAP] Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01286

Datum: 18.10.2021


[ASAP] Development of 2-(5,6,7-Trifluoro-1<italic toggle="yes">H</italic>-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00681

Datum: 18.10.2021


[ASAP] Imaging Autotaxin <italic toggle="yes">In Vivo</italic> with <sup>18</sup>F-Labeled Positron Emission Tomography Ligands

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00913

Datum: 18.10.2021


[ASAP] Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic <sc>d</sc>-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01352

Datum: 18.10.2021


[ASAP] Selection and Identification of Novel Antibacterial Agents against Planktonic Growth and Biofilm Formation of <italic toggle="yes">Enterococcus faecalis</italic>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00939

Datum: 16.10.2021


[ASAP] Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation <italic toggle="yes">In Vivo</italic>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01458

Datum: 15.10.2021


[ASAP] Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01532

Datum: 15.10.2021


[ASAP] Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01477

Datum: 15.10.2021


[ASAP] Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01206

Datum: 15.10.2021


[ASAP] Reactivities of the Front Pocket N-Terminal Cap Cysteines in Human Kinases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01186

Datum: 14.10.2021


[ASAP] Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer’s Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01300

Datum: 14.10.2021


[ASAP] Development of the First Aliphatic <sup>18</sup>F-Labeled Tetrazine Suitable for Pretargeted PET Imaging—Expanding the Bioorthogonal Tool Box

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01326

Datum: 14.10.2021


[ASAP] Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase–Substrate Interaction

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01395

Datum: 14.10.2021


[ASAP] Structure–Activity Relationship of USP5 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00889

Datum: 14.10.2021


[ASAP] Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01451

Datum: 14.10.2021


[ASAP] Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01249

Datum: 14.10.2021


[ASAP] Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01370

Datum: 14.10.2021


[ASAP] Discovery of 6-[(3<italic toggle="yes">S</italic>,4<italic toggle="yes">S</italic>)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01132

Datum: 13.10.2021


[ASAP] Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00828

Datum: 13.10.2021


[ASAP] Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00087

Datum: 13.10.2021


[ASAP] Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01067

Datum: 12.10.2021


[ASAP] Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D<sub>2</sub>/D<sub>3</sub> Receptor Bitopic Ligands

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01353

Datum: 12.10.2021


[ASAP] Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01077

Datum: 11.10.2021


[ASAP] Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01482

Datum: 08.10.2021


[ASAP] Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00886

Datum: 08.10.2021


[ASAP] Small Molecule Kinase Inhibitor Drugs (1995–2021): Medical Indication, Pharmacology, and Synthesis

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00963

Datum: 08.10.2021


[ASAP] Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00655

Datum: 08.10.2021


[ASAP] Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01311

Datum: 08.10.2021


[ASAP] Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by “Inverse Drug Discovery”

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c02024

Datum: 08.10.2021


[ASAP] Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with <italic toggle="yes">In Vivo</italic> Efficacy against MRSA

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01250

Datum: 06.10.2021


[ASAP] Multi-Modal Imaging Probe for Glypican-3 Overexpressed in Orthotopic Hepatocellular Carcinoma

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00697

Datum: 30.09.2021


[ASAP] A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson’s Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01022

Datum: 28.09.2021


[ASAP] Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00566

Datum: 27.09.2021


[ASAP] Noncovalent Interactions with PAMAM and PPI Dendrimers Promote the Cellular Uptake and Photodynamic Activity of Rose Bengal: The Role of the Dendrimer Structure

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01080

Datum: 21.09.2021


[ASAP] Update on the Development of MNK Inhibitors as Therapeutic Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00368

Datum: 17.09.2021


[ASAP] Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00613

Datum: 08.09.2021


 


Category: Current Chemistry Research

Last update: 28.03.2018.






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