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Journal of Medicinal Chemistry

Current research reports and chronological list of recent articles..




The international scientific Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

To search this web page for specific words type "Ctrl" + "F" on your keyboard (Command + "F" on a Mac). Then: type the word you are searching for in the window that pops up!

Additional research articles see Current Chemistry Research Articles. Magazines with similar content (medicinal chemistry):

 - Bioorganic and Medicinal Chemistry Letters,

 - European Journal of Medicinal Chemistry,

 - Journal of Enzyme Inhibition and Medicinal Chemistry,

 - Medicinal Chemistry Research.



Journal of Medicinal Chemistry - Abstracts



[ASAP] Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00218

Datum: 25.06.2019


[ASAP] Identification of Ezetimibe and Pranlukast as Pharmacological Chaperones for the Treatment of the Rare Disease Mucopolysaccharidosis Type IVA

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00428

Datum: 25.06.2019


[ASAP] Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00220

Datum: 25.06.2019


[ASAP] Engineered Substrate for Cyclooxygenase-2: A Pentapeptide Isoconformational to Arachidonic Acid for Managing Inflammation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00823

Datum: 25.06.2019


[ASAP] Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00688

Datum: 25.06.2019


[ASAP] Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00519

Datum: 24.06.2019


[ASAP] Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein–Protein Interaction

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00021

Datum: 22.06.2019


[ASAP] Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00727

Datum: 22.06.2019


[ASAP] Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against <italic toggle="yes">Helicobacter pylori</italic> Drug-Resistant Clinical Strains and in <italic toggle="yes">Helicobacter pylori</italic>-Infected Mice

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00355

Datum: 21.06.2019


[ASAP] Linker Optimization and Therapeutic Evaluation of Phosphatidylserine-Targeting Zinc Dipicolylamine-based Drug Conjugates

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00173

Datum: 20.06.2019


[ASAP] Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00781

Datum: 20.06.2019


[ASAP] Improvement of Asparagine Ethylenediamines as Anti-malarial <italic toggle="yes">Plasmodium</italic>-Selective Proteasome Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00363

Datum: 20.06.2019


[ASAP] (<italic toggle="yes">S</italic>)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00525

Datum: 20.06.2019


[ASAP] Correction to “Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors”

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00852

Datum: 19.06.2019


[ASAP] A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00145

Datum: 19.06.2019


[ASAP] Design, Synthesis, and Structure–Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-a Motif Kinase (ZAK) Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00664

Datum: 17.06.2019


[ASAP] Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00631

Datum: 17.06.2019


[ASAP] Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3-<italic toggle="yes">b</italic>]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00136

Datum: 12.06.2019


[ASAP] Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the “Selectivity Pocket”, Substrate-Binding Site, and NAD<sup>+</sup>-Binding Site

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00255

Datum: 12.06.2019


[ASAP] Correction to Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00877

Datum: 12.06.2019


[ASAP] Correction to “Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine”

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00844

Datum: 12.06.2019


[ASAP] Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00517

Datum: 07.06.2019


[ASAP] Five-Membered <italic toggle="yes">N</italic>-Heterocyclic Scaffolds as Novel Amino Bioisosteres at ?-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00026

Datum: 05.06.2019


[ASAP] Nitric Oxide-Releasing Selective Estrogen Receptor Modulators: A Bifunctional Approach to Improve the Therapeutic Index

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00171

Datum: 04.06.2019


[ASAP] Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00390

Datum: 29.05.2019


[ASAP] Overview of Recent Strategic Advances in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00359

Datum: 28.05.2019


[ASAP] Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00017

Datum: 28.05.2019


[ASAP] <italic toggle="yes">N</italic>-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[<italic toggle="yes">d</italic>]thiazol-2-yl)cyclopropanecarboxamide (TAK-632) Analogues as Novel Necroptosis Inhibitors by Targeting Receptor-Interacting Protein Kinase 3 (RIPK3): Synthesis, Structure–Activity Relationships, and in Vivo Efficacy

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00611

Datum: 28.05.2019


[ASAP] Halogens in Protein–Ligand Binding Mechanism: A Structural Perspective

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b01453

Datum: 28.05.2019


[ASAP] Hydroxyl Groups in Synthetic and Natural-Product-Derived Therapeutics: A Perspective on a Common Functional Group

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00179

Datum: 28.05.2019


[ASAP] Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00439

Datum: 24.05.2019


[ASAP] Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00335

Datum: 23.05.2019


[ASAP] Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00184

Datum: 16.05.2019


[ASAP] Antibiotic Adjuvants: Make Antibiotics Great Again!

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b01781

Datum: 16.05.2019


[ASAP] Design and Discovery of <italic toggle="yes">N</italic>-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00161

Datum: 16.05.2019


[ASAP] Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics<subtitle>Miniperspective</subtitle>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b01891

Datum: 09.05.2019


[ASAP] Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na<sub>V</sub>1.7

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b01906

Datum: 07.05.2019


[ASAP] Pharmacological Chaperones for the Treatment of a-Mannosidosis

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00153

Datum: 02.05.2019


[ASAP] Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00246

Datum: 26.04.2019


[ASAP] Design and Identification of a Novel, Functionally Subtype Selective GABA<sub>A</sub> Positive Allosteric Modulator (PF-06372865)

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00322

Datum: 26.04.2019


[ASAP] Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00182

Datum: 25.04.2019


[ASAP] Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00188

Datum: 24.04.2019


[ASAP] Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00370

Datum: 18.04.2019


[ASAP] Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases<subtitle>Miniperspective</subtitle>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b01954

Datum: 17.04.2019


[ASAP] Recent Advances in the Exploration of Therapeutic Analogues of Gramicidin S, an Old but Still Potent Antimicrobial Peptide

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00156

Datum: 17.04.2019


[ASAP] Targeting the Thioredoxin System as a Strategy for Cancer Therapy<subtitle>Miniperspective</subtitle>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b01595

Datum: 16.04.2019


[ASAP] Synthetic Approaches to the New Drugs Approved During 2017

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00196

Datum: 15.04.2019


[ASAP] Fifty Years in Search of Selective Antiviral Drugs<subtitle>Miniperspective</subtitle>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00175

Datum: 12.04.2019


[ASAP] Vitamin D and Its Synthetic Analogs

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00208

Datum: 02.04.2019


[ASAP] Deciphering the Rules of in Silico Autophagy Methods for Expediting Medicinal Research<subtitle>Miniperspective</subtitle>

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b01673

Datum: 28.03.2019


 


Category: Current Chemistry Research

Last update: 28.03.2018.






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