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Journal of Medicinal Chemistry

Current research reports and chronological list of recent articles..




The international scientific Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

To search this web page for specific words type "Ctrl" + "F" on your keyboard (Command + "F" on a Mac). Then: type the word you are searching for in the window that pops up!

Additional research articles see Current Chemistry Research Articles. Magazines with similar content (medicinal chemistry):

 - Bioorganic and Medicinal Chemistry Letters,

 - European Journal of Medicinal Chemistry,

 - Journal of Enzyme Inhibition and Medicinal Chemistry,

 - Medicinal Chemistry Research.



Journal of Medicinal Chemistry - Abstracts



[ASAP] Synthetic Sansanmycin Analogues as Potent <italic toggle="yes">Mycobacterium tuberculosis</italic> Translocase I Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01407

Datum: 30.11.2021


[ASAP] Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01380

Datum: 30.11.2021


[ASAP] Dual Cathepsin B and Glutathione-Activated Dimeric and Trimeric Phthalocyanine-Based Photodynamic Molecular Beacons for Targeted Photodynamic Therapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01634

Datum: 30.11.2021


[ASAP] New Insights into the Structure–Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of <bold>Neurounina-1</bold> as Modulators of the Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Isoforms

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01212

Datum: 30.11.2021


[ASAP] Searching for New Microbiome-Targeted Therapeutics through a Drug Repurposing Approach

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01333

Datum: 30.11.2021


[ASAP] Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00946

Datum: 30.11.2021


[ASAP] First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00605

Datum: 29.11.2021


[ASAP] Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01411

Datum: 29.11.2021


[ASAP] Modulation of Naturally Occurring Linear Dipeptide Chirality to Reduce the Affinity for Oligopeptide Transporter 1 and Increase Intestinal Stability for an Enhanced Colon-Targeting Effect in the Treatment of Inflammatory Bowel Disease: An Application of <italic toggle="yes">trans</italic>-4-<sc>l</sc>-Hydroxyprolyl-<sc>l</sc>-serine

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01276

Datum: 29.11.2021


[ASAP] Relaxed Substrate Requirements of Sterol 14α-Demethylase from <italic toggle="yes">Naegleria fowleri</italic> Are Accompanied by Resistance to Inhibition

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01710

Datum: 29.11.2021


[ASAP] Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-<italic toggle="yes">N</italic>-(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure–Activity Relationship and Preclinical Characterization

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01403

Datum: 29.11.2021


[ASAP] Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01156

Datum: 28.11.2021


[ASAP] The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01663

Datum: 27.11.2021


[ASAP] Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01693

Datum: 25.11.2021


[ASAP] Discovery of Pyrazolo[3,4-<italic toggle="yes">d</italic>]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01205

Datum: 25.11.2021


[ASAP] Stapled Peptides Targeting SARS-CoV-2 Spike Protein HR1 Inhibit the Fusion of Virus to Its Cell Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01681

Datum: 24.11.2021


[ASAP] High-Throughput Screening Platform in Postnatal Heart Cells and Chemical Probe Toolbox to Assess Cardiomyocyte Proliferation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01173

Datum: 24.11.2021


[ASAP] Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01331

Datum: 24.11.2021


[ASAP] Selection of QPX7831, an Orally Bioavailable Prodrug of Boronic Acid β-Lactamase Inhibitor QPX7728

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01722

Datum: 24.11.2021


[ASAP] Targeting of the FOXM1 Oncoprotein by E3 Ligase-Assisted Degradation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01069

Datum: 23.11.2021


[ASAP] Subphthalocyanines as Efficient Photosensitizers with Nanomolar Photodynamic Activity against Cancer Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01584

Datum: 23.11.2021


[ASAP] Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01535

Datum: 23.11.2021


[ASAP] Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01547

Datum: 23.11.2021


[ASAP] Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00804

Datum: 22.11.2021


[ASAP] Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01161

Datum: 22.11.2021


[ASAP] Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00918

Datum: 22.11.2021


[ASAP] Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01287

Datum: 22.11.2021


[ASAP] What is in Our Kit? An Analysis of Building Blocks Used in Medicinal Chemistry Parallel Libraries

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01139

Datum: 22.11.2021


[ASAP] Perspectives on SARS-CoV-2 Main Protease Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00409

Datum: 19.11.2021


[ASAP] Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin E Conjugate

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01157

Datum: 19.11.2021


[ASAP] Engineering of a Biologically Active Insulin Dimer

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01594

Datum: 19.11.2021


[ASAP] Zanamivir–Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01531

Datum: 19.11.2021


[ASAP] COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01254

Datum: 19.11.2021


[ASAP] 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D<sub>2</sub> Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01327

Datum: 19.11.2021


[ASAP] Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Fluorinated Candidates as PI3K Inhibitors: Targeting Fluorophilic Binding Sites

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01674

Datum: 18.11.2021


[ASAP] Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds?

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00390

Datum: 18.11.2021


[ASAP] Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01694

Datum: 18.11.2021


[ASAP] Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5–6-mer) Peptides

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01334

Datum: 17.11.2021


[ASAP] Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01180

Datum: 15.11.2021


[ASAP] From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01163

Datum: 15.11.2021


[ASAP] Noninvasive NIR Imaging of Senescence <italic toggle="yes">via</italic> <italic toggle="yes">In Situ</italic> Labeling

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01313

Datum: 09.11.2021


[ASAP] Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00944

Datum: 08.11.2021


[ASAP] Discovery of (<italic toggle="yes">Z</italic>)-1-(3-((1<italic toggle="yes">H</italic>-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-3-(isoxazol-3-yl)urea Derivatives as Novel and Orally Highly Effective CSF-1R Inhibitors for Potential Colorectal Cancer Immunotherapy

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01184

Datum: 04.11.2021


[ASAP] Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00926

Datum: 04.11.2021


[ASAP] Identification of C5-NH<sub>2</sub> Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01366

Datum: 04.11.2021


[ASAP] Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01494

Datum: 03.11.2021


[ASAP] A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c00981

Datum: 02.11.2021


[ASAP] Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01171

Datum: 02.11.2021


[ASAP] Discovery of a Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist and Its Synergistic Therapy with Prolyl Hydroxylase Inhibitors for the Treatment of Renal Anemia

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01479

Datum: 28.10.2021


[ASAP] Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.1c01475

Datum: 27.10.2021


 


Category: Current Chemistry Research

Last update: 28.03.2018.






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