Hide Menu
Hide Menu   Home   |     About Us   |   Contact   |   Imprint   |   Privacy   |   Sitemap
Hide Menu   Chemistry Index   |   Chemicals   |   Chemical Elements
Hide Menu   Lab Instruments   |  
Hide Menu   Job Vacancies   |  
Hide Menu   Chemistry Forum   |  
Chemistry A - Z
Equipment for Lab and Industry
Chemicals and Compounds
Job Vacancies
Imprint, Contact

 

Chemical Monthly

Current research reports and chronological list of recent articles..




The international scientific journal Chemical Monthly was originally conceived as an Austrian journal of chemistry, and has evolved into an international journal covering all branches of chemistry. It features the most recent research in analytical, inorganic, medicinal, organic, physical, structural, and theoretical chemistry, including chemically oriented areas of biochemistry.

The publisher is Springer. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

To search this web page for specific words type "Ctrl" + "F" on your keyboard (Command + "F" on a Mac). Then: type the word you are searching for in the window that pops up!

Additional research articles in the field of general chemistry, see Current Chemistry Research Articles. Magazines with similar content:

 - Angewandte Chemie International Edition,

 - Chemical Communications,

 - The Chemical Record,

 - Chemistry Central Journal,

 - Chemistry Letters,

 - Journal of the American Chemical Society,

 - Nature Chemistry.



Chemical Monthly - Abstracts



Fabrication of PAMP/Au and GO/PAMP/Au nanosensors for electrochemical detection of paracetamol in pharmaceutical preparations

Abstract

This paper reports on the modification of Pencil Graphite Electrode (PGE) surface with the poly(2-amino-4-methylphenol)/gold (PAMP/Au) and graphene oxide/poly(2-amino-4-methylphenol)/gold (GO/PAMP/Au) nanocomposites, in two steps. The first step is based on the one-pot preparation of composites by template-free chemical oxidation process. In the second step, composites are deposited at PGE surface by electro-oxidation process. Both nanocomposites and modified PGE surfaces are characterized by X-Ray Diffraction method (XRD), Scanning Electron Microscopy (SEM), EDAX, and CV analyses. The electrochemical performances of modified electrodes (abbreviated as PAMP/Au-PGE and GO/PAMP/Au-PGE) were investigated. The limit of detection values for PGE, PAMP/Au-PGE, and GO/PAMP/Au-PGE were found to be 2.74 × 10–6, 5.29 × 10–7, and 2.91 × 10–8 mol/dm3, respectively. The limit of quantification values were determined as 9.14 × 10–6, 1.76 × 10–6, and 9.69 × 10–8 mol/dm3 for PGE, PAMP/Au-PGE, and GO/PAMP/Au-PGE, respectively.

Graphical Abstract


Datum: 01.12.2021


Synthesis and photo-physicochemical properties of phthalocyanines substituted with sterically hindered phenol

Abstract

Synthesis of the Zn, Mg, and LuOAc phthalocyanines (Pcs) containing sterically hindered 2,6-di-(tert-butyl)-4-methylphenol group were successfully achieved by the cyclotetramerization of the 4-[2,6-di-(tert-butyl)-4-methylphenoxy]phthalonitrile. All compounds were fully characterized by 1H and 13C NMR, infrared, elemental analysis, UV–Vis, and MALDI-TOF spectral data. The photo-physicochemical properties of the targeted molecules include fluorescence quantum yields, lifetimes, singlet oxygen generation, and photodegradation quantum yields were recorded in dimethyl sulfoxide.

Graphical abstract


Datum: 01.12.2021


Stereoselective synthesis of homochiral paracyclophanylindenofuranylimidazo[3.3.3]propellanes

Abstract

The reaction between N-paracyclophanyl-substituted hydrazine-carbothioamides and dicyanomethylene-1,3-indanedione (CNIND) furnished planar and central chiral substituted (epiminomethanoimino)-indenofuranyl-1,4-(1,4-dibenzenocyclohexaphane)-1,2-carboxamides as a type of paracyclophanylfuroimidazo[3.3.3]propellanes in 35–81% yields as a major product as single diastereomers, and substituted spiro[indene-2,4′-indenopyran]-3′-carbonitrile (9–12% yields) as a minor product. To prepare the homochiral paracyclophanylpropellane, oxidation of scalemic formylparacyclophane afforded the corresponding acid. Afterward, the acid chloride formation of [2.2]paracyclophane was obtained by chlorination of the corresponding acid. By repeating the previous procedure and utilizing a final HPLC purification, we succeeded in obtaining the target homochiral propellane. Various spectroscopic techniques such as mass spectrometry, 1H NMR, 13C NMR, and X-ray analysis have been used for structure determination and confirmation of the stereochemistry of the isolated products.

Graphic abstract


Datum: 01.12.2021


Sensitive voltammetric determination of oxymetazoline hydrochloride at a disposable electrode

Abstract

In this work, sensitive voltammetric determination of oxymetazoline based on its oxidation has been described at a cheap, disposable, and easily prepared pre-treated pencil graphite electrode. The recorded cyclic voltammograms proved that the oxidation response of oxymetazoline goes linearly in the concentration range between 0.25 and 500 µM. The limit of detection and sensitivity of the sensor were found as 0.08 µM and 256.0 µA mM−1 cm−2, respectively. The obtained results confirmed that applied pre-treatment procedure on pencil graphite electrode provides a high voltammetric response and sensitivity towards determination of oxymetazoline. The results (0.0496% ± 0.0003 oxymetazoline) from the real sample studies on a nasal drop (including 0.05% oxymetazoline) indicated that the designed sensor has a high potential for selective, accurate, and sensitive determination of oxymetazoline in pharmaceutical samples.

Graphical abstract


Datum: 01.12.2021


Highly sensitive direct simultaneous determination of zinc(II), cadmium(II), lead(II), and copper(II) based on in-situ-bismuth and mercury thin-film plated screen-printed carbon electrode

Abstract

Thin-film disposable screen-printed electrodes modified in situ with bismuth and mercury coatings to enhance the simultaneous sensitivities and the limits of detection of cadmium(II), lead(II), copper(II), and zinc(II) were prepared using anodic stripping voltammetry. Whether the films coated were properly adhered to the surface were checked by energy-dispersive X-ray spectroscopy, electrochemical impedance spectroscopy, and cyclic voltammetry. The optimum conditions for the best performance of the sensor were investigated. The modification with Bi/Hg film electrode exhibited good analytical performance, with excellent repeatability (RSD < 4.0%), reproducibility (RSD < 4.0%), and reasonable interferences by various inorganic species. Bi/HgSPC electrode also offers low detection limits for Zn(II), Cd(II), Pb(II), and Cu(II), i.e., 0.97 ppb, 0.16 ppb, 0.082 ppb, and 0.64 ppb, respectively. The developed method was applied to a certified reference water sample and a surface water sample taken from the environment by standard addition method and the results are satisfactory. Analytical results obtained with the sensor are comparable to those obtained by the inductively coupled plasma mass spectrometry.

Graphical abstract


Datum: 01.12.2021


Hydrogen bond and nucleophilicity motifs in the design of molecular probes for CN− and F− ions

Abstract

A large number of molecular receptors have been reported for the detection and estimation of cyanide and fluoride ions in chemical, biological, environmental, and industrial processes. The design of such receptors is chiefly linked to specific interaction between them and the target anions. Though hydrogen bond formation is of prime importance, it has been observed that specificity and selectivity of cyanide over fluoride can be achieved by utilizing small size of fluoride and strong nucleophilic but weak basic character of cyanide. Recent results reveal enormous utility of complexation, de-complexation and metallo-supramolecular strategies for the target purpose. These developments signal the advent of more sensitive recognition systems for selecting multi-ion toxicants through a common molecular receptor. This communication scrutinizes results from recent literature on neutral molecular receptors for recognition of cyanide and fluoride ions and elaborates on principles that can be deployed for future developments in the area.

Graphical abstract


Datum: 01.12.2021


The basic features of thermodynamics

Abstract

More than 100 years ago a Swedish schoolteacher Nils Engelbrektsson could theoretically derive the thermodynamic equation of state, which is universally valid. His colleague, a Swedish schoolteacher Karl Franzén had experimentally verified his inferences and could prove their validity. About hundred years of fierce struggle to persuade the colleagues do finally bring the desiderated victory to Nils and Karl: their trains of thoughts do deserve our careful looking at them. That is just the main idea behind the translation at hand [1. E. B. Starikov (2019) A Different Thermodynamics and Its True Heroes, Jenny Stanford Publishing, Singapore; 2. Entropy-Enthalpy Compensation: Finding a Methodological Common Denominator through Probability, Statistics, Physics, E. B. Starikov, Bengt Nordén, Shigenori Tanaka, Editors; Jenny Stanford Publishing, Singapore, 2020].

Graphic abstract


Datum: 01.12.2021


Effect of positive In(III) doped in nickel oxide nanostructure at modified glassy carbon electrode for determination of allura red in soft drink powders

Abstract

The current study aimed to modify a glassy carbon electrode with raspberry-like In3+/NiO hierarchical nanostructure as a novel and highly sensitive electrochemical sensor for effectively detection of allura red colorant, which was then characterized by techniques of energy-dispersive X-ray analysis, scanning electron microscopy, and X-ray diffraction. Electrochemical impedance spectroscopy, cyclic voltammetry, differential pulse voltammetry, and chronoamperometry were employed to calculate the oxidation peak current of colorant, resulting in linear range of 0.01–700 µM (R2 = 0.9999) and limit of detection of 4.1 nM. The developed modifier was practically recruited for the detection of allura red in phosphate buffer solution (pH 4) as well as the real samples of soft drinks, the results of which successfully showed a high performance for the electrode.

Graphical abstract


Datum: 01.12.2021


Binding of α-lipoic acid to human serum albumin: spectroscopic and molecular modeling studies

Abstract

α-Lipoic acid as an antioxidant is used in the treatment of many diseases, such as diabetes, cardiovascular diseases, cancer, and AIDS. The objective of this study was to investigate the capability of human serum albumin (HSA) as a potential carrier for α-lipoic acid (α-LA). Molecular interactions between HSA and α-LA were monitored via fluorescence and circular dichroism spectroscopies as well as molecular docking and molecular dynamics simulations studies. The results revealed that α-LA binds to HSA with binding stoichiometry of 1:1 through hydrogen bonding and van der Waals interactions. The overall binding affinity was estimated to be of the order 105 M−1. α-LA induced partial folding in the tertiary structure and subtle alterations in the secondary structure of HSA, which was accompanied by increased thermal stability. The results also demonstrated that the complex formation between α-LA and HSA enhanced photostability under UV irradiation. The improved antioxidant activity of α-LA in electron donation was amongst the positive influences observed through the association of α-LA with HSA. Thus, their complexes can successfully be employed in the food and pharmaceutical industries.

Graphic abstract


Datum: 01.12.2021


Synthesis and spectroscopic investigation of azo derivatives of 4,6-dihydroxy-2-methylpyrimidine

Abstract

Three novel pyrimidine azo dyes having hetereoaromatic diazo component were prepared through a diazo coupling reaction between 4,6-dihydroxy-2-methypyrimidine and diazotised 2-amino-thiazole and 2-amino-(6-subtituted)benzothiazole(s). Their chemical structures were confirmed by using FT-IR, proton and carbon NMR spectroscopy, liquid chromatography/mass spectrometry, and elemental microanalysis techniques. FT-IR spectra of these dyes in solid state show that they exist in hydrazon tautomeric forms. 1H NMR spectral data in dimethyl sulfoxide indicates that they are predominantly consistent with the hydrazon tautomeric form. The effects of solvent, acid–base, and temperature on the absorption spectra of the dyes were investigated. In the UV–Vis absorption spectra of the dyes in different solvents, there are no linear changing in maximum absorption wavelength values as depending on solvent polarity. The dyes show positive solvatochromism in chloroform and glacial acetic acid (AA) and also one shows more bathochromic shift. UV–Vis absorption spectra recorded at approximately 50 °C of the dyes have no significant change. To detail the properties of the absorption and reveal possible differences on the chemical structure, the data of the dyes were compared with those given for some dyes in the literature. UV–Vis absorption spectra of all dyes in methanol + HCl show that λmax values of literature dyes have more hypsochromic shifts on contrary to those of methanol + NaOH and dyes reported here have less bathochromic shift. The results show that these dyes may be suitable for applications in the textile industry.

Graphic abstract


Datum: 01.12.2021


BF3 adsorption on pure, Al-doped, and Sc-doped graphene-like BC3: a DFT study

Abstract

The adsorption of boron trifluoride was explored onto pure, Al-doped, and Sc-doped BC3 nanosheets through density functional theory computations. As BF3 approaches the BC3, its adsorption releases 17.2–23.9 kJ/mol of energy, indicating a weak BF3 adsorption. Also, the electronic properties of the nanosheet do not change meaningfully. Unlike the Al-doping, Sc-doping advances the performance of the BC3 and makes it more reactive and sensitive to BF3. According to the calculations, the BF3 adsorption reduces the HOMO/LUMO gap of the Sc-doped boron carbide from 2.39 to 1.48 eV (~  − 38.1%), which can be concluded that the electrical conductivity of the nanosheet has increased. But Al-doped could not meaningfully modify the electronic properties of BC3 in the presence of BF3. Thus, the Sc-doped boron carbide can generate electrical signals when the BF3 molecules approach, being a promising sensor.

Graphical abstract


Datum: 01.12.2021


Electrocatalytic oxidation and flow injection analysis of formaldehyde at binary metal oxides (Co3O4–NiO and CuO–Co3O4) modified pencil graphite electrodes

Abstract

In this work, a highly efficient performance of bimetallic thin films as their oxide forms (Co3O4–NiO and CuO–Co3O4) modified on pencil graphite electrodes (PGEs) was presented for electrocatalytic oxidation of formaldehyde. In addition, a sensitive and selective amperometric determination of formaldehyde in flow injection analysis system have been first performed using binary transition metal oxides modified PGEs. Co3O4–NiO and CuO–Co3O4 films were electrochemically deposited on the PGE surface using cyclic voltammetric procedures. The recorded cyclic voltammograms in the presence of formaldehyde in 0.10 M NaOH containing 0.10 M KCl showed that the prepared binary transition metal oxides modified PGEs exhibited a higher electrocatalytic activity than single metal oxide thin films modified PGEs towards oxidation of formaldehyde. The linear responses based on electrocatalytic oxidation of formaldehyde were determined as 2.5–5000 μM and 0.25–1000 μM for Co3O4–NiO/PGE and CuO–Co3O4/PGE, respectively. Moreover, limit of detections and sensitivities were estimated as 0.73 μM and 81.8 μA mM−1 cm−2 and 0.09 μM and 166 μA mM−1 cm−2 for Co3O4–NiO/PGE and CuO–Co3O4/PGE, respectively. The results from real sample studies proved that the fabricated FI-amperometric sensors enable high applicability towards determination of formaldehyde in real water samples.

Graphical abstract


Datum: 01.12.2021


Secondary metabolites of Anthocephalus chinensis (Lamk.): a concise review

Abstract

Anthocephalus chinensis (Lamk.) (ACL) is a traditional plant from the Rubiaceae family that has been employed as an Indian traditional folk medicine for hundreds of years in India. In this review, we compiled the published studies of the past 50 years (1971–2021) that were related to chemical constituents having significant pharmacologic activities. Approximately 93 compounds have been isolated from different parts of this plant mainly as monoterpene indole alkaloids, triterpenoids, polyphenols, and their glycosides. These chemical constituents support the various pharmacological properties such as fever, uterine disorders, blood diseases, and leprosy, etc. ACL also has been used as crude traditional drug for the treatment of other ailments, but efficacy, safety and clinical utilities are insufficient from a scientific point of view. This review, thus, covers the structural diversity of secondary metabolites of ACL and their potential pharmacological properties to render the interest that would help in their commercialization as potential therapeutic agents. The present work also highlighted the use of column chromatography methods (for example silica gel, Sephadex LH20, and HPLC techniques) to isolate and purify the compounds, especially indole alkaloids. Thus, our study provides a collection of chemical constituents from ACL that may be a source of traditional drugs with possible therapeutic effects for the treatment of various diseases.

Graphical abstract


Datum: 30.11.2021


Hydroalcoholic mixtures: the effect of the solvent on the electronic spectrum of the indicator methyl orange

Abstract

In this study, the behavior of the electronic spectrum of the indicator methyl orange in water–methanol, water–ethanol, water–n-propanol, water–iso-propanol and water–t-butanol mixtures was investigated. The spectroscopic parameters were calculated for the binary mixtures with changes in the mole fraction of water in the mixture. Interesting changes in the profile of the indicator methyl orange were observed in these mixtures, showing synergistic and preferential solvation effects. The aim of this study was to evaluate the physical–chemical properties of methyl orange in binary mixtures, considering the use of this compound as a perichromic indicator. Due to changes in the electronic spectrum in hydroalcoholic binary mixtures, methyl orange can act as a colorimetric sensor for the detection of short-chain alcohols in the presence of water.

Graphical abstract


Datum: 26.11.2021


The analysis of interactions between DNA and small molecules: proposals for binding mechanisms based on computational data

Abstract

Derivatives of amine, azepane, pyrrolidine, and piperazines are important structural moieties found in many biologically active molecules whose chemical structures can also be designed as drug. Also the presence of nitrogen in these compounds enables the quaternization and ionic structure which is required for water solubility. Phthalocyanines appended with this kind of nitrogen-containing compounds have the ability to dissolve in water and can be used in photodynamic therapy as anticancer agents. In our previous work, 2-(azepane-1-yl)ethanol, 2,4,6-tris(N,N-dimethylaminomethyl)phenol, and 1-methylpyrrolidin-2-ylmethanol were attached with silicon phthalocyanines (Pcs) and mainly photodynamic therapy was experimented rather than their interactions with DNA. In this work, compounds 2-(azepane-1-yl)ethanol, 2,4,6-tris(N,N-dimethylaminomethyl)-phenol, and 1-methylpyrrolidin-2-ylmethanol free from phthalocyanines and 4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid were treated with calf-thymus DNA to test whether these nitrogen-containing compounds have more effects on binding mechanisms with DNA except making phthalocyanines water soluble. The results indicated that compounds 2-(azepane-1-yl)-ethanol, 4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid, and 1-methylpyrrolidin-2-ylmethanol bind to minor grooves of DNA while compound 2,4,6-tris(N,N-dimethylaminomethyl)phenol exhibited intercalative properties. The active sites of these compounds were guanine-cytosine which is important for cancer treatment. All binding processes were entropy driven and hydrogen bonds were strong according to calculated lengths of bonds. Compared to phthalocyanine-attached forms, they have direct and dominant effects on binding with DNA in Pc free forms.

Graphical abstract


Datum: 24.11.2021


Oxidation of triethanolamine by ceric ammonium sulfate in aqueous sulfuric acid: spectrophotometric kinetic and mechanistic study

Abstract

Oxidation kinetics of triethanolamine by ceric ammonium sulfate in aqueous sulfuric acid has been studied spectrophotometrically in contexts of many physicochemical processes. Stoichiometry of the reaction is found to be 1:6. Contrary to the literature findings the reaction proceeds without the presence of any transition metals acting as catalysts. Oxidation kinetics shows unit order dependence on oxidant, Ce(IV) and substrate, triethanolamine as well. Complex, fractional inverse order dependence on [H+], unaltered rate in the presence of added products at the initial stage and inverse dependence on added salt, sodium bisulfate are the findings. With increase in the solvent polarity, rate of the reaction also increased. Activation and thermodynamic parameters are computed from the temperature dependence observations. Suitable kinetic model and explanations are provided considering all the findings with a proposal of formation of an activated complex of the type [Ce(IV)-triethanolamine].

Graphical abstract


Datum: 23.11.2021


Catalytic one-pot three-component synthesis of 3,3′-disubstituted oxindoles and spirooxindole pyrans by mixed ligand transition metal complexes

Abstract

New three-component reaction was developed via one-pot strategy for the synthesis of functionalized 3,3′-disubstituted oxindoles and spirooxindole through the reaction among isatin, malononitrile, and acetone/indole/nitromethane/acetylacetone/dimedone in ethanol as solvent without base. It was observed that all the mixed ligand transition metal complexes with triphenylphosphine worked as the efficient catalysts. The present methodology agreements several advantages, including simplicity of the preparation and handling of the catalyst, simple and easy work-up, short reaction times, high yields of the products.

Graphical abstract


Datum: 17.11.2021


Electrochemical sensing of antibiotic drug amoxicillin in the presence of dopamine at simple and selective carbon paste electrode activated with cetyltrimethylammonium bromide surfactant

Abstract

The effective, selective, and electrochemically steady cetyltrimethylammonium bromide drop-casted carbon paste electrode was constructed for the detection of amoxicillin in presence of dopamine through cyclic voltammetry method. The modified and unmodified electrode materials were characterized by various methods like field emission scanning electron microscopy, cyclic voltammetry, and electrochemical impedance spectroscopy with acceptable results. The constructed modified sensor delivers a higher electrocatalytic nature for the oxidation of 0.1 mM amoxicillin in 0.1 M phosphate buffer saline of 6.5 pH with high peak current and lower peak potential than the bare carbon paste electrode. The analytical applicability of modified electrode for amoxicillin electro-oxidation was detected by increasing the amoxicillin concentration in the range from 10 to 150 µM with fine limit of detection and the limit of quantification of 5.90 µM and 19.67 µM, respectively. This article discloses a facile and recommended approach for the concurrent inspection of amoxicillin in the presence of dopamine. The modified sensor gives high stability, repeatability, reproducibility, and sensitivity. The premeditated method and modified sensor give a fine recovery for amoxicillin detection in medication sample.

Graphical abstract


Datum: 16.11.2021


H3PMo7W5O40·24H2O catalyzed access to fused pyrazolopyranopyrimidine derivatives via one-pot multicomponent synthesis: green chemistry

Abstract

An economic, sustainable, and straightforward environmentally friendly route for synthesis of 3-methyl-4-aryl-1,4-dihydropyrazolo[4ʹ,3ʹ:5,6]pyrano[2,3-d]pyrimidine-5,7(6H,8H)-diones via condensation of ethyl acetoacetate, hydrazine hydrate, barbituric acid, and aromatic aldehydes in the presence of catalytic amount of H3PMo7W5O40·24H2O under solvent-free condition was reported. This environmentally benign protocol offers selective synthesis of pyrazolopyranopyrimidine derivatives without any side product with excellent yield in shorter time.

Graphical abstract


Datum: 13.11.2021


Correction to: An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)


Datum: 01.11.2021


 


Category: Current Chemistry Research

Last update: 28.03.2018.






© 1996 - 2020 Internetchemistry














I agree!

This site uses cookies. By using this website, you agree to the use of cookies! Learn more ...