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Nature Chemical Biology

Current research reports and chronological list of recent articles..




Nature Chemical Biology is a monthly research journal of science that that publishes original research in three formats (Brief Communications, Letters and Articles), as well as News and Views, reviews, perspectives, commentaries, book reviews, meeting reports, research highlights and editorials covering all research at the interface of chemistry and biology.

The publisher is the Nature Publishing Group. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

To search this web page for specific words type "Ctrl" + "F" on your keyboard (Command + "F" on a Mac). Then: type the word you are searching for in the window that pops up!

Additional research articles see Current Chemistry Research Articles. Magazines with similar content (chemical biology):

 - ACS Chemical Biology,

 - BMC Chemical Biology,

 - Chemical Biology and Drug Design,

 - ChemBioChem,

 - Current Opinion in Chemical Biology,



Nature Chemical Biology - Abstracts



Tuned out

Nature Chemical Biology, Published online: 19 May 2022; doi:10.1038/s41589-022-01037-z

Controlling kinase inhibitors’ residence time via reversible covalent binding is of high interest in drug discovery. Tuning reversible covalent binding kinetics using a pan-kinase inhibitor that reacts with the catalytic lysine enabled exquisite temporal selectivity in vitro and in vivo.
Datum: 19.05.2022


Tuned out

Nature Chemical Biology, Published online: 19 May 2022; doi:10.1038/s41589-022-01037-z

Controlling kinase inhibitors’ residence time via reversible covalent binding is of high interest in drug discovery. Tuning reversible covalent binding kinetics using a pan-kinase inhibitor that reacts with the catalytic lysine enabled exquisite temporal selectivity in vitro and in vivo.
Datum: 19.05.2022


Reversible lysine-targeted probes reveal residence time-based kinase selectivity

Nature Chemical Biology, Published online: 19 May 2022; doi:10.1038/s41589-022-01019-1

The linking of salicylaldehydes to a kinase binding scaffold resulted in the development of reversible, lysine-targeted covalent kinase inhibitors with enhanced residence time.
Datum: 19.05.2022


Reversible lysine-targeted probes reveal residence time-based kinase selectivity

Nature Chemical Biology, Published online: 19 May 2022; doi:10.1038/s41589-022-01019-1

The linking of salicylaldehydes to a kinase binding scaffold resulted in the development of reversible, lysine-targeted covalent kinase inhibitors with enhanced residence time.
Datum: 19.05.2022


Putting introns on retainer

Nature Chemical Biology, Published online: 16 May 2022; doi:10.1038/s41589-022-01025-3

Protein arginine methyltransferases (PRMTs) are overexpressed in many cancer types, including triple-negative breast cancer (TNBC). A new study shows that a reversible inhibitor of type I PRMTs suppresses TNBC tumor growth by inducing a viral mimicry response with retained introns.
Datum: 16.05.2022


PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Nature Chemical Biology, Published online: 16 May 2022; doi:10.1038/s41589-022-01024-4

Type I PRMT inhibition elicits potent antitumor activity associated with increased interferon response and intron-retained dsRNA accumulation, suggesting its potential combination with immune checkpoint inhibitors for cancer treatment.
Datum: 16.05.2022


Putting introns on retainer

Nature Chemical Biology, Published online: 16 May 2022; doi:10.1038/s41589-022-01025-3

Protein arginine methyltransferases (PRMTs) are overexpressed in many cancer types, including triple-negative breast cancer (TNBC). A new study shows that a reversible inhibitor of type I PRMTs suppresses TNBC tumor growth by inducing a viral mimicry response with retained introns.
Datum: 16.05.2022


PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Nature Chemical Biology, Published online: 16 May 2022; doi:10.1038/s41589-022-01024-4

Type I PRMT inhibition elicits potent antitumor activity associated with increased interferon response and intron-retained dsRNA accumulation, suggesting its potential combination with immune checkpoint inhibitors for cancer treatment.
Datum: 16.05.2022


Chemical editing of proteoglycan architecture

Nature Chemical Biology, Published online: 12 May 2022; doi:10.1038/s41589-022-01023-5

A modular approach for synthesis of proteoglycan glycoconjugates relies on bioorthogonal glycosylation of alkyne-tagged core proteins with azide-tagged glycosaminoglycans to enable the analysis of their functional roles on mammalian cell surfaces.
Datum: 12.05.2022


Chemical editing of proteoglycan architecture

Nature Chemical Biology, Published online: 12 May 2022; doi:10.1038/s41589-022-01023-5

A modular approach for synthesis of proteoglycan glycoconjugates relies on bioorthogonal glycosylation of alkyne-tagged core proteins with azide-tagged glycosaminoglycans to enable the analysis of their functional roles on mammalian cell surfaces.
Datum: 12.05.2022


Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases

Nature Chemical Biology, Published online: 05 May 2022; doi:10.1038/s41589-022-01018-2

Biochemical and structural characterization of the bifunctional lanthipeptide protease EryP enables identification of a regulatory interdomain calcium-binding site and leads to a strategy to engineer related enzymes for enhanced catalytic activity.
Datum: 05.05.2022


Cell-type-specific labeling and profiling of glycans in living mice

Nature Chemical Biology, Published online: 05 May 2022; doi:10.1038/s41589-022-01016-4

A genetically encoded metabolic glycan labeling (GeMGL) method based on an orthogonal engineered enzyme–unnatural sugar pair was developed for cell-type-specific glycan labeling in cells and living mice.
Datum: 05.05.2022


Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases

Nature Chemical Biology, Published online: 05 May 2022; doi:10.1038/s41589-022-01018-2

Biochemical and structural characterization of the bifunctional lanthipeptide protease EryP enables identification of a regulatory interdomain calcium-binding site and leads to a strategy to engineer related enzymes for enhanced catalytic activity.
Datum: 05.05.2022


Cell-type-specific labeling and profiling of glycans in living mice

Nature Chemical Biology, Published online: 05 May 2022; doi:10.1038/s41589-022-01016-4

A genetically encoded metabolic glycan labeling (GeMGL) method based on an orthogonal engineered enzyme–unnatural sugar pair was developed for cell-type-specific glycan labeling in cells and living mice.
Datum: 05.05.2022


A vicious cycle

Nature Chemical Biology, Published online: 28 April 2022; doi:10.1038/s41589-022-01032-4

A vicious cycle
Datum: 28.04.2022


A vicious cycle

Nature Chemical Biology, Published online: 28 April 2022; doi:10.1038/s41589-022-01032-4

A vicious cycle
Datum: 28.04.2022


 


Category: Current Chemistry Research

Last update: 28.03.2018.






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