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Published: 04.01.2011

Dendronized Polymers

From molecule to object: largest synthetic structure with molecular precision.

Organic Chemists have always been trying to imitate biology. Although it is possible to make many molecules that imitate biomolecules in terms of structure and function, it remains a challenge to attain the size and form of large biomolecules.

An international team led by A. Dieter Schlüter at the ETH Zurich (Switzerland) has now introduced a branched polymer that resembles the tobacco mosaic virus in size and cylindrical form.

As the researchers outline in the journal Angewandte Chemie, this is the largest synthetic macromolecule with defined shape and atomic structure reported to date.

Linear macromolecule PG5

Pushing the limits: A 200×106 Da structurally defined, linear macromolecule (PG5) has a molar mass, cross-section dimension, and cylindrical shape that are comparable to some naturally occurring objects, such as amyloid fibrils or certain plant viruses. The macromolecule is resistant against flattening out on a surface; the picture shows PG5 embracing the tobacco mosaic virus (TMV).

[Credit: Angewandte Chemie]

Previously, the largest reported synthetic structures with a defined atomic structure were polystyrene polymers with a molecular mass of about 40 million Daltons. However, this value corresponds to a small fraction of the mass of large DNA molecules. Formation of a large synthetic molecule that also has a defined form is much more difficult. For biologists, however, it is routine. Even the simplest organism has a well-defined form, such as the rod-shaped tobacco mosaic virus. For chemists it is a model: a massive molecular ensemble with perfect control over its chemical structure, function, size, and molecular form.

Schlüter and co-workers have now presented a branched polymer that approximates the size and form of the tobacco mosaic virus. Their complex synthesis, which requires 170,000 bond-forming reactions in a single molecule, led to a structurally defined, linear macromolecule with a diameter of about 10 nm and a molecular weight of 200 million Daltons. It thus has a molar mass, cross section, and cylindrical form comparable to the tobacco mosaic virus.

The new macromolecule is a dendronized polymer: it consists of a linear backbone with highly and regularly branched side chains. “This is the biggest synthetic macromolecule with a defined chemical structure and defined form to date,” according to Schlüter. “Our experiment is a first step toward the synthesis of molecular objects.” A structure is considered to be an object if it keeps its form regardless of its environment, when its interior can be distinguished from the outer environment, and when there is a clear boundary between the two. There are many synthetic nano-objects, however these are not single molecules, but are aggregates of several or many individual molecules.


Further Information and Source:
Dr. Baozhong Zhang, Dr. Roger Wepf, Dr. Karl Fischer, Prof. Manfred Schmidt, Dr. Sébastien Besse, Dr. Peter Lindner, Prof. Benjamin T. King, Dr. Reinhard Sigel, Prof. Peter Schurtenberger, Prof. Yeshayahu Talmon, Dr. Yi Ding, Prof. Martin Kröger9, Prof. Avraham Halperin, Prof. A. Dieter Schlüter:
The Largest Synthetic Structure with Molecular Precision: Towards a Molecular Object.
In: Angewandte Chemie International Edition; first published online: 22 December 2010
DOI: 10.1002/anie.201005164
URL: direct link
A. Dieter Schlüter, ETH Zürich, Switzerland
Source: Angewandte Chemie International Edition, press release 48/2010
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