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Toxicogenomics

Information and institutions in the field of toxicogenomics.




Toxicogenomics is a scientific discipline and research area that studies how the genome is involved in responses to environmental stressors and toxicants. It combines toxicology with genomics to understand the role of gene-environment interactions in diseases, and also offers the opportunity to develop tests that require fewer laboratory animals or cause them less inconvenience

Toxicogenomics uses or combines methods and approaches from toxicology, genomics, transcriptomics, proteomics, metabolomics and other, as well as computer-assisted information technologies.

Pharmaceutical research defines toxicogenomics as the study of the structure and function of the genome under the influence of foreign substances (xenobiotics); here, toxicogenomics is a toxicological subdiscipline of pharmacogenomics. The aim is the prediction of individual reactions after the application of medicinal active substances (drugs).

The concept of toxicogenomics is by no means universally accepted; alternative terms - such as chemogenomics - have been proposed in the literature for this subject area.

The following overview contains information sources on toxicogenomics as well as facilities dealing with toxicogenomic questions.



Content, Topics


Current Articles
General Information
Lecture Notes, Tutorials
Methods
Data and Databases
Articles and Reports
Research facilities and departments
Organisations



Current Articles


Genomic technologies to identify toxic chemicals should be developed
A new report recommends that government agencies enhance their efforts to incorporate genomic data into risk assessments of chemicals and medicines ... Article Oct, 2007

NAS report offers new tools to assess health risks from chemicals
Toxicogenomic technologies provide tools to better understand the mechanisms through which environmental agents initiate and advance disease processes ... Article Oct, 2007



General Information


Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
NAS report offers new tools to assess health risks from chemicals; Oct 2007

Genetic Terms
NCI Dictionary of Genetics Terms

Glossaries of Genetic Terminology
reflects official WHO use of genomic terminology

Standardization initiatives in the (eco)toxicogenomics domain
A review in Comp Funct Genom 2004; 5: 633 - 641; Wiley; doi: 10.1002/cfg.447

The Principles and Practice of Toxicogenomics
Applications and Opportunities. Article by the Society of Toxicology; 2000 - Format: PDF

Toxicogenomics
An Overview of Toxicogenomics. Article: Curr. Issues Mol. Biol. (2002) 4: 45-56 - Format: PDF

Toxicogenomics
An Approach to Using Toxicogenomic Data in U.S.. EPA, USA

Toxicogenomics
Textbook

What is Toxicogenomics
PDF Article - Format: PDF



Lecture Notes, Tutorials


Toxicogenomics and ist Applications
Article, 2016 - Format: PDF



Methods




Data and Databases


Comparative Toxicogenomics Database, CTD
The CTD elucidates molecular mechanisms by which environmental chemicals affect human disease



Articles and Reports


Application of toxicogenomics to the endocrine disruption issue
Article: Pure Appl. Chem., Vol. 75, Nos. 11 - 12, pp. 2419 - 2422, 2003. IUPAC, USA - Format: PDF

Database Development in Toxicogenomics: Issues and Efforts
Article: Environmental Health Perspectives. EHP, USA

Practical Application of Toxicogenomics in Early Drug Discovery
Article, Abbott 2007 - Format: PDF



Research facilities and departments


Hannover, Germany
Chair for Pharmaco- and Toxicogenomics at Hannover Medical School, MHH



Organisations


OECD
Activities to Explore and Evaluate Regulatory Application of Genomic Methods; Toxicogenomics

 


Last update: 14.11.2018.






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