Organic Letters

Current research reports and chronological list of recent articles.


The international scientific journal Organic Letters serves as the international forum for the communication of important research in all branches of the theory and practice of: organic chemistry (including organometallic and materials chemistry); physical and theoretical organic chemistry; natural products isolation and synthesis; new synthetic methodology; bioorganic and medicinal chemistry.

The publisher is the American Chemical Society, ACS. The copyright and publishing rights of specialized products listed below are in this publishing house. This is also responsible for the content shown.

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Additional research articles see Current Chemistry Research Articles. Magazines with similar content (organic chemistry):

 - Beilstein Journal of Organic Chemistry.

 - European Journal of Organic Chemistry.

 - Journal of Organic Chemistry.

 - Journal of Physical Organic Chemistry.

 - Organic Process Research and Development.

 - Russian Journal of Organic Chemistry.

 - Synlett.



Organic Letters - Abstracts



Correction to “Rhodium-Catalyzed Synthesis of Benzosilolometallocenes via the Dehydrogenative Silylation of C(sp2)–H Bonds”

Organic Letters
DOI: 10.1021/acs.orglett.6b01399

Datum: 27.05.2016


Synthesis of Demissidine and Solanidine

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Organic Letters
DOI: 10.1021/acs.orglett.6b01320

Datum: 27.05.2016


Synthesis of Fluorenes Starting from 2-Iodobiphenyls and CH2Br2 through Palladium-Catalyzed Dual C–C Bond Formation

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Organic Letters
DOI: 10.1021/acs.orglett.6b01300

Datum: 27.05.2016


Thermal [2 + 2]-Cycloaddition of Ketenes with Chiral Enol Ethers: Route to Densely Substituted Cyclobutanones

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Organic Letters
DOI: 10.1021/acs.orglett.6b01058

Datum: 27.05.2016


Phosphine-Catalyzed Intramolecular Cyclizations of α-Nitroethylallenoates Forming (Z)-Furanone Oximes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01299

Datum: 27.05.2016


Stereoselective Rh-Catalyzed Hydrogenative Desymmetrization of Achiral Substituted 1,4-Dienes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01088

Datum: 27.05.2016


Euphorikanin A, a Diterpenoid Lactone with a Fused 5/6/7/3 Ring System from Euphorbia kansui

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Organic Letters
DOI: 10.1021/acs.orglett.6b01093

Datum: 27.05.2016


Total Synthesis of the GRP78-Downregulatory Macrolide (+)-Prunustatin A, the Immunosuppressant (+)-SW-163A, and a JBIR-04 Diastereoisomer That Confirms JBIR-04 Has Nonidentical Stereochemistry to (+)-Prunustatin A

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Organic Letters
DOI: 10.1021/acs.orglett.6b01235

Datum: 27.05.2016


Aryl–Allene Cyclization via a Hg(OTf)2-Catalytic Pathway

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Organic Letters
DOI: 10.1021/acs.orglett.6b01144

Datum: 27.05.2016


Silver-Mediated anti-Markovnikov and Markovnikov-Selective Hydrotrifluoromethylthiolation of Terminal Alkynes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01286

Datum: 26.05.2016


A General Catalyst for Site-Selective C(sp3)–H Bond Amination of Activated Secondary over Tertiary Alkyl C(sp3)–H Bonds

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Organic Letters
DOI: 10.1021/acs.orglett.6b01392

Datum: 26.05.2016


Kinetically Blocked Stable 5,6:12,13-Dibenzozethrene: A Laterally π-Extended Zethrene with Enhanced Diradical Character

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Organic Letters
DOI: 10.1021/acs.orglett.6b01196

Datum: 26.05.2016


Palladium-Catalyzed Annulation of Internal Alkynes: Direct Access to π-Conjugated Ullazines

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Organic Letters
DOI: 10.1021/acs.orglett.6b01182

Datum: 26.05.2016


Divergent Synthesis of Quinazolin-4(3H)-ones and Tryptanthrins Enabled by a tert-Butyl Hydroperoxide/K3PO4-Promoted Oxidative Cyclization of Isatins at Room Temperature

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Organic Letters
DOI: 10.1021/acs.orglett.6b01291

Datum: 26.05.2016


Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes Enabled by an Electron-Donor–Acceptor Complex of Togni’s Reagent with a Tertiary Amine

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Organic Letters
DOI: 10.1021/acs.orglett.6b01301

Datum: 26.05.2016


Ir(III)-Catalyzed Carbenoid Functionalization of Benzamides: Synthesis of N-Methoxyisoquinolinediones and N-Methoxyisoquinolinones

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Organic Letters
DOI: 10.1021/acs.orglett.6b01072

Datum: 26.05.2016


Heteroarene-Directed Oxidative sp2 C–H Bond Allylation with Aliphatic Alkenes Catalyzed by an (Electron-Deficient η5-Cyclopentadienyl)rhodium(III) Complex

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Organic Letters
DOI: 10.1021/acs.orglett.6b01288

Datum: 26.05.2016


Ciliatonoids A and B, Two Limonoids from Toona ciliata

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Organic Letters
DOI: 10.1021/acs.orglett.6b01213

Datum: 26.05.2016


Diastereoselective Synthesis of 5-Heteroaryl-Substituted Prolines Useful for Controlling Peptide-Bond Geometry

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Organic Letters
DOI: 10.1021/acs.orglett.6b00863

Datum: 26.05.2016


Synthesis of Indole-Substituted Indanones via Palladium(II)-Catalyzed Tandem Reaction of ortho-Electron-Deficient Alkynyl-Substituted Aryl Aldehydes with Indoles

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Organic Letters
DOI: 10.1021/acs.orglett.6b01240

Datum: 26.05.2016


Visible Light Driven Photocascade Catalysis: Ru(bpy)3(PF6)2/TBHP-Mediated Synthesis of Fused β-Carbolines in Batch and Flow Microreactors

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Organic Letters
DOI: 10.1021/acs.orglett.6b01321

Datum: 26.05.2016


Total Syntheses of Isowondonins Based on a Biosynthetic Pathway

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Organic Letters
DOI: 10.1021/acs.orglett.6b01336

Datum: 26.05.2016


Single-Electron Transmetalation: Protecting-Group-Independent Synthesis of Secondary Benzylic Alcohol Derivatives via Photoredox/Nickel Dual Catalysis

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Organic Letters
DOI: 10.1021/acs.orglett.6b00911

Datum: 24.05.2016


Phosphine-Catalyzed [3 + 3]-Domino Cycloaddition of Ynones and Azomethine Imines To Construct Functionalized Hydropyridazine Derivatives

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Organic Letters
DOI: 10.1021/acs.orglett.6b00988

Datum: 24.05.2016


[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates

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Organic Letters
DOI: 10.1021/acs.orglett.6b01104

Datum: 24.05.2016


5-Methylisoxazole-3-carboxamide-Directed Palladium-Catalyzed γ-C(sp3)–H Acetoxylation and Application to the Synthesis of γ-Mercapto Amino Acids for Native Chemical Ligation

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Organic Letters
DOI: 10.1021/acs.orglett.6b01160

Datum: 24.05.2016


Chemoselective Schwartz Reagent Mediated Reduction of Isocyanates to Formamides

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Organic Letters
DOI: 10.1021/acs.orglett.6b01226

Datum: 24.05.2016


Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species

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Organic Letters
DOI: 10.1021/acs.orglett.6b00810

Datum: 24.05.2016


Metal-Free Mediated Meerwein-Type Reaction: A Radical Cascade Arylation/Aryl Migration/Desulfonylation of Conjugated Alkenes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01041

Datum: 24.05.2016


Amidines for Versatile Cobalt(III)-Catalyzed Synthesis of Isoquinolines through C–H Functionalization with Diazo Compounds

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Organic Letters
DOI: 10.1021/acs.orglett.6b01199

Datum: 24.05.2016


Synthesis of 3-Substituted Aryl[4,5]isothiazoles through an All-Heteroatom Wittig-Equivalent Process

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Organic Letters
DOI: 10.1021/acs.orglett.6b01338

Datum: 24.05.2016


A New Multicomponent Multicatalyst Reaction (MC)2R: Chemoselective Cycloaddition and Latent Catalyst Activation for the Synthesis of Fully Substituted 1,2,3-Triazoles

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Organic Letters
DOI: 10.1021/acs.orglett.6b00975

Datum: 23.05.2016


Tandem Incorporation of Enantiomeric Residues Engenders Discrete Peptoid Structures

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Organic Letters
DOI: 10.1021/acs.orglett.6b01283

Datum: 23.05.2016


Ru-Catalyzed Asymmetric Hydrogenative/Transfer Hydrogenative Desymmetrization of Meso-Epoxy Diketones

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Organic Letters
DOI: 10.1021/acs.orglett.6b01073

Datum: 23.05.2016


Metal-Free Reduction of Aromatic Nitro Compounds to Aromatic Amines with B2pin2 in Isopropanol

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Organic Letters
DOI: 10.1021/acs.orglett.6b01274

Datum: 23.05.2016


Diels–Alder Reactions of Furans with Itaconic Anhydride: Overcoming Unfavorable Thermodynamics

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Organic Letters
DOI: 10.1021/acs.orglett.6b00929

Datum: 23.05.2016


Synthesis and Chiroptical Properties of a Ring-Fused BODIPY with a Skewed Chiral π Skeleton

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Organic Letters
DOI: 10.1021/acs.orglett.6b01237

Datum: 23.05.2016


Asymmetric Arylation of Imines Catalyzed by Heterogeneous Chiral Rhodium Nanoparticles

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Organic Letters
DOI: 10.1021/acs.orglett.6b01172

Datum: 23.05.2016


Palladium-Catalyzed Highly Chemoselective Intramolecular C–H Aminocarbonylation of Phenethylamines to Six-Membered Benzolactams

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Organic Letters
DOI: 10.1021/acs.orglett.6b01171

Datum: 23.05.2016


Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C–S Bond Cleavage

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Organic Letters
DOI: 10.1021/acs.orglett.6b01250

Datum: 23.05.2016


Revisited Mechanistic Implications of the Joullié–Ugi Three-Component Reaction

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Organic Letters
DOI: 10.1021/acs.orglett.6b00827

Datum: 23.05.2016


Acceptorless Dehydrogenative Coupling of o-Aminobenzamides with the Activation of Methanol as a C1 Source for the Construction of Quinazolinones

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Organic Letters
DOI: 10.1021/acs.orglett.6b00925

Datum: 23.05.2016


Organocatalyzed Enantioselective Direct Mannich Reaction of α-Styrylacetates

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Organic Letters
DOI: 10.1021/acs.orglett.6b01087

Datum: 23.05.2016


Rhodium-Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of α,ω-Diynes with Unsymmetrical 1,2-Disubstituted Alkenes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01116

Datum: 23.05.2016


Cyclic Anti-Azacarboxylation of 2-Alkynylanilines with Carbon Dioxide

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Organic Letters
DOI: 10.1021/acs.orglett.6b00884

Datum: 23.05.2016


Axial Chirality about Boron–Carbon Bond: Atropisomeric Azaborines

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Organic Letters
DOI: 10.1021/acs.orglett.6b01159

Datum: 20.05.2016


Ruthenium-Catalyzed Enantioselective Hydrogenation of 1,8-Naphthyridine Derivatives

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Organic Letters
DOI: 10.1021/acs.orglett.6b01186

Datum: 20.05.2016


Palladium(II)-Catalyzed Cross-Dehydrogenative Coupling (CDC) of N-Phthaloyl Dehydroalanine Esters with Simple Arenes: Stereoselective Synthesis of Z-Dehydrophenylalanine Derivatives

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Organic Letters
DOI: 10.1021/acs.orglett.6b01255

Datum: 20.05.2016


[3 + 1]- and [3 + 2]-Cycloadditions of Azaoxyallyl Cations and Sulfur Ylides

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Organic Letters
DOI: 10.1021/acs.orglett.6b01194

Datum: 20.05.2016


C–O/C–H Coupling of Polyfluoroarenes with Aryl Carbamates by Cooperative Ni/Cu Catalysis

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Organic Letters
DOI: 10.1021/acs.orglett.6b00819

Datum: 20.05.2016


Synthesis of Chiral Fluorinated Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation

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Organic Letters
DOI: 10.1021/acs.orglett.6b01118

Datum: 19.05.2016


Gymnopeptides A and B, Cyclic Octadecapeptides from the Mushroom Gymnopus fusipes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01158

Datum: 19.05.2016


Chiral Ferrocenyl P,N-Ligands for Palladium-Catalyzed Asymmetric Formal [3 + 2] Cycloaddition of Propargylic Esters with β-Ketoesters: Access to Functionalized Chiral 2,3-Dihydrofurans

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Organic Letters
DOI: 10.1021/acs.orglett.6b01192

Datum: 19.05.2016


Synthesis of the Cortistatin Pentacyclic Core by Alkoxide-Directed Metallacycle-Mediated Annulative Cross-Coupling

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Organic Letters
DOI: 10.1021/acs.orglett.6b01048

Datum: 19.05.2016


Acetohydrazone: A Transient Directing Group for Arylation of Unactivated C(sp3)–H Bonds

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Organic Letters
DOI: 10.1021/acs.orglett.6b01170

Datum: 19.05.2016


Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2-Pyridyl Sulfone

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Organic Letters
DOI: 10.1021/acs.orglett.6b01258

Datum: 19.05.2016


Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C–H Activation

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Organic Letters
DOI: 10.1021/acs.orglett.6b00751

Datum: 19.05.2016


Synthesis of [60]Fullerene-Fused Spiroindanes by Palladium-Catalyzed Oxidative Annulation of [60]Fullerene with 2-Aryl Cyclic 1,3-Dicarbonyl Compounds

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Organic Letters
DOI: 10.1021/acs.orglett.6b01043

Datum: 18.05.2016


SnAP-eX Reagents for the Synthesis of Exocyclic 3-Amino- and 3-Alkoxypyrrolidines and Piperidines from Aldehydes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01099

Datum: 18.05.2016


Synthesis of Polysubstituted Benzoic Esters from 1,2-Dihydropyridines and Its Application to the Synthesis of Fluorenones

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Organic Letters
DOI: 10.1021/acs.orglett.6b01260

Datum: 18.05.2016


Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives

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Organic Letters
DOI: 10.1021/acs.orglett.6b00967

Datum: 18.05.2016


Total Synthesis of Teixobactin

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Organic Letters
DOI: 10.1021/acs.orglett.6b01324

Datum: 18.05.2016


Photochemical Generation of Benzyl Cations That Selectively Cross-Link Guanine and Cytosine in DNA

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Organic Letters
DOI: 10.1021/acs.orglett.6b00755

Datum: 18.05.2016


Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification

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Organic Letters
DOI: 10.1021/acs.orglett.6b00983

Datum: 18.05.2016


tert-Butyl Nitrite: Organic Redox Cocatalyst for Aerobic Aldehyde-Selective Wacker–Tsuji Oxidation

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Organic Letters
DOI: 10.1021/acs.orglett.6b01165

Datum: 18.05.2016


Manganese(II)/Picolinic Acid Catalyst System for Epoxidation of Olefins

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Organic Letters
DOI: 10.1021/acs.orglett.6b00518

Datum: 18.05.2016


Synthesis of 9,10-Phenanthrenes via Palladium-Catalyzed Aryne Annulation by o-Halostyrenes and Formal Synthesis of (±)-Tylophorine

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Organic Letters
DOI: 10.1021/acs.orglett.6b00558

Datum: 18.05.2016


Fe-Catalyzed Hydroalkylation of Olefins with para-Quinone Methides

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Organic Letters
DOI: 10.1021/acs.orglett.6b01173

Datum: 18.05.2016


Chiral Sensor for Enantiodiscrimination of Varied Acids

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Organic Letters
DOI: 10.1021/acs.orglett.6b00088

Datum: 18.05.2016


Palladium-Catalyzed Regioselective Difluoroalkylation and Carbonylation of Alkynes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01038

Datum: 18.05.2016


Correction to Synthesis of Omphadiol and Pyxidatol C

Organic Letters
DOI: 10.1021/acs.orglett.6b01361

Datum: 17.05.2016


Generation of the Methoxycarbonyl Radical by Visible-Light Photoredox Catalysis and Its Conjugate Addition with Electron-Deficient Olefins

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Organic Letters
DOI: 10.1021/acs.orglett.6b00895

Datum: 17.05.2016


Ag(I)-Catalyzed Indolization/C3-Functionalization Cascade of 2-Ethynylanilines via Ring Opening of Donor–Acceptor Cyclopropanes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01057

Datum: 17.05.2016


Tetrahydroquinolines via Stereospecific [3 + 3]-Annulation of Donor–Acceptor Cyclopropanes with Nitrosoarenes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01302

Datum: 17.05.2016


Direct Diastereo- and Enantioselective Vinylogous Michael Additions of Linear Enones

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Organic Letters
DOI: 10.1021/acs.orglett.6b01050

Datum: 17.05.2016


Palladium-Catalyzed Carboxylation of Activated Vinylcyclopropanes with CO2

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Organic Letters
DOI: 10.1021/acs.orglett.6b01231

Datum: 17.05.2016


Construction of Cyclic Sulfamidates Bearing Two gem-Diaryl Stereocenters through a Rhodium-Catalyzed Stepwise Asymmetric Arylation Protocol

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Organic Letters
DOI: 10.1021/acs.orglett.6b01183

Datum: 17.05.2016


Application of Ynamides in the Synthesis of 2-(Tosylamido)- and 2,5-Bis(tosylamido)thiophenes

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Organic Letters
DOI: 10.1021/acs.orglett.6b01101

Datum: 17.05.2016


A Catalytic Peterson-like Synthesis of Alkenyl Nitriles

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Organic Letters
DOI: 10.1021/acs.orglett.6b01121

Datum: 17.05.2016


EtAlCl2/2,6-Disubstituted Pyridine-Mediated Carboxylation of Alkenes with Carbon Dioxide

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Organic Letters
DOI: 10.1021/acs.orglett.6b00918

Datum: 17.05.2016


Asymmetric Roadmap to Diverse Polycyclic Benzopyrans via Phosphine-Catalyzed Enantioselective [4 + 2]-Annulation Reaction

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Organic Letters
DOI: 10.1021/acs.orglett.6b01030

Datum: 17.05.2016


Cross-Coupling of Acrylamides and Maleimides under Rhodium Catalysis: Controlled Olefin Migration

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Organic Letters
DOI: 10.1021/acs.orglett.6b00909

Datum: 16.05.2016


Synthesis and Structure of Corona[6](het)arenes Containing Mixed Bridge Units

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Organic Letters
DOI: 10.1021/acs.orglett.6b01112

Datum: 16.05.2016


Expanding Diversity without Protecting Groups: (+)-Sclareolide to Indolosesquiterpene Alkaloid Mycoleptodiscin A and Analogues

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Organic Letters
DOI: 10.1021/acs.orglett.6b01145

Datum: 16.05.2016


Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa

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Organic Letters
DOI: 10.1021/acs.orglett.6b00979

Datum: 13.05.2016


Synthesis of the Privileged 8-Arylmenthol Class by Radical Arylation of Isopulegol

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Organic Letters
DOI: 10.1021/acs.orglett.6b01047

Datum: 13.05.2016


Chiral Phosphoric Acid Catalyzed Diastereo- and Enantioselective Mannich-Type Reaction between Enamides and Thiazolones

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Organic Letters
DOI: 10.1021/acs.orglett.6b00857

Datum: 13.05.2016


Gold-Catalyzed Photoredox C(sp2) Cyclization: Formal Synthesis of (±)-Triptolide

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Organic Letters
DOI: 10.1021/acs.orglett.6b00968

Datum: 13.05.2016


4-Toluenesulfonyloxymethyl-(H)-phosphinate: A Reagent for the Introduction of O- and S-Methyl-(H)-phosphinate Moieties

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Organic Letters
DOI: 10.1021/acs.orglett.6b01167

Datum: 13.05.2016


Asymmetric Autocatalysis as a Relay for Remote Amplification of Chirality of Target Molecules Used as Triggers

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Organic Letters
DOI: 10.1021/acs.orglett.6b00742

Datum: 13.05.2016


2-Aminophenyl-1H-pyrazole as a Removable Directing Group for Copper-Mediated C–H Amidation and Sulfonamidation

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Organic Letters
DOI: 10.1021/acs.orglett.6b01105

Datum: 12.05.2016


Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators

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Organic Letters
DOI: 10.1021/acs.orglett.6b01222

Datum: 12.05.2016


Dragonbloodin A1 and A2: Flavan Trimers and Anti-inflammatory Principles from Sanguis Draconis

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Organic Letters
DOI: 10.1021/acs.orglett.6b00593

Datum: 11.04.2016






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