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Journal of Organic Chemistry - Current Research Articles



Current research articles: Organic Chemistry

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Journal of Organic Chemistry - Editor: American Chemical Society, ACS

JOC welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry.




Current articles of the journal:



Copper Acetate–DMSO Promoted Methylthiolation of Arenes and Heteroarenes

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00443

Posted on 31 March 2015 | 7:42 pm


An SNAr Approach to Sterically Hindered ortho-Alkoxybenzaldehydes for the Synthesis of Olefin Metathesis Catalysts

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00563

Posted on 31 March 2015 | 7:41 pm


Iridium-Catalyzed Single-Step N-Substituted Lactam Synthesis from Lactones and Amines

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00101

Posted on 31 March 2015 | 12:31 pm


An Enantioselective Approach to Functionalized Amino Acids: Total Synthesis of Antiepileptic Drug (R)-Lacosamide

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00480

Posted on 31 March 2015 | 12:30 pm


Silica-Mediated Synthesis of Indolinooxazolidine-Based Molecular Switches

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00282

Posted on 31 March 2015 | 12:30 pm


Palladium(II)-Catalyzed Directed Trifluoromethylthiolation of Unactivated C(sp3)–H Bonds

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00505

Posted on 30 March 2015 | 10:13 pm


Palladium-Catalyzed Tandem Annulation: A Strategy To Construct 2,3-Difunctionalized Benzofuran Derivatives in Ionic Liquids

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00154

Posted on 30 March 2015 | 8:57 pm


Metal-Free Synthesis of Indole via NIS-Mediated Cascade C–N Bond Formation/Aromatization

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00090

Posted on 30 March 2015 | 4:24 pm


Asymmetric Robinson-Type Annulation Reaction between ?-Ketoamides and ?,?-Unsaturated Ketones

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The Journal of Organic Chemistry
DOI: 10.1021/jo502904n

Posted on 30 March 2015 | 2:23 pm


Isoquinolone Synthesis through SNAr Reaction of 2-Halobenzonitriles with Ketones Followed by Cyclization

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00357

Posted on 30 March 2015 | 12:51 pm


Transition-Metal-Free Hydration of Nitriles Using Potassium tert-Butoxide under Anhydrous Conditions

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The Journal of Organic Chemistry
DOI: 10.1021/jo502752u

Posted on 27 March 2015 | 4:26 pm


Selective Synthesis of Alkylboronates by Copper(I)-Catalyzed Borylation of Allyl or Vinyl Arenes

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The Journal of Organic Chemistry
DOI: 10.1021/jo502606x

Posted on 27 March 2015 | 2:45 pm


Chemoenzymatic Asymmetric Synthesis of 1,4-Benzoxazine Derivatives: Application in the Synthesis of a Levofloxacin Precursor

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00056

Posted on 27 March 2015 | 1:10 pm


Palladium-meta-Terarylphosphine Catalyst for the Mizoroki–Heck Reaction of (Hetero)Aryl Bromides and Functional Olefins

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00386

Posted on 27 March 2015 | 5:28 am


Design of Pyrazolo-pyrrolo-pyrazines and Pyrazolo-pyrrolo-diazepines via AuCl3-Catalyzed and NaH-Supported Cyclization of N-Propargyl Pyrazoles

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00034

Posted on 26 March 2015 | 6:52 pm


Synthesis and Enzymatic Studies of Bisubstrate Analogues for Farnesyl Diphosphate Synthase

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00202

Posted on 26 March 2015 | 12:58 pm


Ni-Catalyzed Highly Chemo-, Regio-, and Enantioselective Decarboxylative Aldol Reaction of ?,?-Unsaturated ?-Ketoesters with ?-Ketoacids

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The Journal of Organic Chemistry
DOI: 10.1021/jo502741z

Posted on 26 March 2015 | 11:48 am


Synthesis and Chemical Reactivity of Tetrahydro[60]fullerene Epoxides with Both Amino and Aryl Addends

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00287

Posted on 26 March 2015 | 11:47 am


Synthesis and Structural Analysis of Angular Monoprotected Diamines Based on Spiro[3.3]heptane Scaffold

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00323

Posted on 25 March 2015 | 7:18 pm


Substituent-Controlled Annuloselectivity and Stereoselectivity in the Sulfa-Staudinger Cycloadditions

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00312

Posted on 25 March 2015 | 7:16 pm


Development of Orthogonally Protected Hypusine for Solid-Phase Peptide Synthesis

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00110

Posted on 24 March 2015 | 8:46 pm


Synthesis of Polyhydroxylated Piperidine and Pyrrolidine Peptidomimetics via One-Pot Sequential Lactam Reduction/Joullie?–Ugi Reaction

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00335

Posted on 24 March 2015 | 2:01 pm


Chemoenzymatic Synthesis of Vitamin B5-Intermediate (R)-Pantolactone via Combined Asymmetric Organo- and Biocatalysis

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The Journal of Organic Chemistry
DOI: 10.1021/jo502667x

Posted on 23 March 2015 | 6:57 pm


Toluene Dioxygenase-Catalyzed Synthesis and Reactions of cis-Diol Metabolites Derived from 2- and 3-Methoxyphenols

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The Journal of Organic Chemistry
DOI: 10.1021/jo5028968

Posted on 23 March 2015 | 11:18 am


Copper-Catalyzed Selective Arylations of Benzoxazoles with Aryl Iodides

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00019

Posted on 23 March 2015 | 11:17 am


Synthesis and Properties of 6?-Fluoro-tricyclo-DNA

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00184

Posted on 20 March 2015 | 2:49 pm


Rh(III)-Catalyzed Oxidative Annulation of 2-Phenylimidazo[1,2-a]pyridines with Alkynes: Mono versus Double C–H Activation

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00059

Posted on 20 March 2015 | 1:35 pm


Iodine-Catalyzed Oxidative Cross-Coupling of Indoles and Azoles: Regioselective Synthesis of N-Linked 2-(Azol-1-yl)indole Derivatives

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The Journal of Organic Chemistry
DOI: 10.1021/jo502933e

Posted on 20 March 2015 | 1:28 pm


Synthesis and Characterization of Bis-N-2-Aryl Triazole as a Fluorophore

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00006

Posted on 20 March 2015 | 1:26 pm


Rhodium Catalyzed C2-Selective Cyanation of Indoles and Pyrroles

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00142

Posted on 19 March 2015 | 2:45 pm


Rhodium Catalyzed Arylation of Diazo Compounds with Aryl Boronic Acids

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The Journal of Organic Chemistry
DOI: 10.1021/jo502922r

Posted on 19 March 2015 | 2:26 pm


Ru-Catalyzed Asymmetric Transfer Hydrogenation of ?-Trifluoromethylimines

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00177

Posted on 19 March 2015 | 2:15 pm


Reacting Cyclopropenones with Arynes: Access to Spirocyclic Xanthene–Cyclopropene Motifs

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00330

Posted on 19 March 2015 | 1:55 pm


Hybrid [n]Arenes through Thermodynamically Driven Macrocyclization Reactions

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00099

Posted on 18 March 2015 | 7:10 pm


Origin of Chemoselectivity in N-Heterocyclic Carbene Catalyzed Cross-Benzoin Reactions: DFT and Experimental Insights

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00301

Posted on 18 March 2015 | 3:36 pm


Stereoselective Synthesis of Chiral Sulfilimines from N-Mesyloxycarbamates: Metal-Nitrenes versus Metal-Nitrenoids Species

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00256

Posted on 18 March 2015 | 2:00 pm


Generation of bis-Acyl Ketals from Esters and Benzyl Amines Under Oxidative Conditions

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The Journal of Organic Chemistry
DOI: 10.1021/jo502903d

Posted on 18 March 2015 | 1:29 pm


Theoretical Insight into the Mechanism of Gold(I)-Catalyzed Rearrangement of 2-Propargyl 2H-Azirines to Pyridines

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00180

Posted on 18 March 2015 | 5:38 am


Iron-Catalyzed N-Arylsulfonamide Formation through Directly Using Nitroarenes as Nitrogen Sources

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00130

Posted on 18 March 2015 | 5:36 am


Synthesis of Aryl anti-Vicinal Diamines via Aza-Brook Rearrangement-Initiated Nucleophilic Addition of ?-Silylamines to Imines

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00255

Posted on 17 March 2015 | 1:26 pm


Intermolecular Reductive Coupling of Esters with Benzophenones by Low-Valent Titanium: Synthesis of Diarylmethyl Ketones Revisited

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00102

Posted on 17 March 2015 | 12:38 pm


Transition Metal-Free Generation of N-Unsubstituted Imines from Benzyl Azides: Synthesis of N-Unsubstituted Homoallylic Amines

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The Journal of Organic Chemistry
DOI: 10.1021/jo502794q

Posted on 17 March 2015 | 12:37 pm


Synthesis of Chiral 2,3-Disubstituted 1,4-Diazabicyclo[2.2.2]octane Derivatives

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The Journal of Organic Chemistry
DOI: 10.1021/jo502688b

Posted on 17 March 2015 | 12:37 pm


Chiroptical Studies on Brevianamide B: Vibrational and Electronic Circular Dichroism Confronted

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The Journal of Organic Chemistry
DOI: 10.1021/jo5022647

Posted on 17 March 2015 | 5:57 am


Palladium-Catalyzed Intramolecular Cyclization of Ynamides: Synthesis of 4-Halo-oxazolones

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00071

Posted on 16 March 2015 | 3:01 pm


Enantioselective Synthesis of Tunable Chiral Clickphine P,N-Ligands and Their Application in Ir-Catalyzed Asymmetric Hydrogenation

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00438

Posted on 16 March 2015 | 2:17 pm


Synthesis and Evaluation of Hydroxymethylaminocyclitols as Glycosidase Inhibitors

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00133

Posted on 16 March 2015 | 2:17 pm


Room-Temperature Transition-Metal-Free One-Pot Synthesis of 3-Aryl Imidazo[1,2-a]pyridines via Iodo-hemiaminal Intermediate

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00298

Posted on 16 March 2015 | 1:30 pm


A One-Pot O-Sulfinative Passerini/Oxidation Reaction: Synthesis of ?-(Sulfonyloxy)amide Derivatives

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00131

Posted on 13 March 2015 | 4:06 pm


Air Oxidative Radical Hydroxysulfurization of Styrenes Leading to ?-Hydroxysulfides

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00123

Posted on 13 March 2015 | 3:27 pm


Bromination of Olefins with HBr and DMSO

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00211

Posted on 12 March 2015 | 11:56 am


Origin of the Regioselective Reduction of Chlorins

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00137

Posted on 6 March 2015 | 2:41 pm


Effects of Thionation and Fluorination on Cis–Trans Isomerization in Tertiary Amides: An Investigation of N-Alkylglycine (Peptoid) Rotamers

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00048

Posted on 4 March 2015 | 4:40 pm


Mechanistic Insight into the Dehydro-Diels–Alder Reaction of Styrene–Ynes

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00200

Posted on 2 March 2015 | 2:49 pm


Synthesis of 1,2-Borazaronaphthalenes from Imines by Base-Promoted Borylation of C–H bond

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The Journal of Organic Chemistry
DOI: 10.1021/jo5029437

Posted on 27 February 2015 | 1:58 pm


Dual Role of Acetanilides: Traceless Removal of a Directing Group through Deacetylation/Diazotation and Palladium-Catalyzed C–C-Coupling Reactions

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b00272

Posted on 24 February 2015 | 6:03 pm





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