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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



Probing the Interactions of Macrolide Antibiotics with Membrane-Mimetics by NMR Spectroscopy

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300647f

Posted on 25 May 2012 | 8:31 pm


Identification of HIV-1 Inhibitors Targeting the Nucleocapsid Protein

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201442t

Posted on 24 May 2012 | 8:59 pm


Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300526r

Posted on 24 May 2012 | 8:59 pm


Characterization and Solubilization of Pyrrole–Imidazole Polyamide Aggregates

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300380a

Posted on 24 May 2012 | 7:29 pm


AM-8553: A Novel MDM2 Inhibitor with a Promising Outlook for Potential Clinical Development

Journal of Medicinal Chemistry
DOI: 10.1021/jm3007068

Posted on 24 May 2012 | 7:29 pm


Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effects in Vitro and Pro-Cognitive and Hepatoprotective Effects in Vivo

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300246n

Posted on 24 May 2012 | 4:22 pm


Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300184s

Posted on 23 May 2012 | 8:33 pm


Novel 3-Nitro-1H-1,2,4-triazole-Based Amides and Sulfonamides as Potential Antitrypanosomal Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300508n

Posted on 23 May 2012 | 4:36 pm


A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300280e

Posted on 23 May 2012 | 2:54 pm


Metallocene-Based Inhibitors of Cancer-Associated Carbonic Anhydrase Enzymes IX and XII

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300427m

Posted on 22 May 2012 | 4:50 pm


Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300260v

Posted on 22 May 2012 | 4:27 pm


Protein–Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase

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Journal of Medicinal Chemistry
DOI: 10.1021/jm3004043

Posted on 21 May 2012 | 10:05 pm


Cytotoxic Effects of Combination of Oxidosqualene Cyclase Inhibitors with Atorvastatin in Human Cancer Cells

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300256z

Posted on 21 May 2012 | 10:00 pm


A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300534u

Posted on 21 May 2012 | 9:27 pm


Discovery and Optimization of a Series of 2-Aryl-4-Amino-5-(3?,4?,5?-trimethoxybenzoyl)Thiazoles as Novel Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300388h

Posted on 21 May 2012 | 8:46 pm


Correction to Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors

Journal of Medicinal Chemistry
DOI: 10.1021/jm300560g

Posted on 18 May 2012 | 5:23 pm


Synthesis and Biological Evaluation of New Amino Acid and Dipeptide Derivatives of Neocryptolepine as Anticancer Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300468t

Posted on 18 May 2012 | 4:52 pm


Identification of a Novel Family of BRAFV600E Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm3004416

Posted on 18 May 2012 | 4:11 pm


Water-Soluble Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as Human A3 Adenosine Receptor Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300323t

Posted on 18 May 2012 | 4:09 pm


In Vitro Anticancer Activity of cis-Diammineplatinum(II) Complexes with ?-Diketonate Leaving Group Ligands

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Journal of Medicinal Chemistry
DOI: 10.1021/jm3002857

Posted on 18 May 2012 | 7:00 am


Thiophene Bioisosteres of Spirocyclic ? Receptor Ligands: Relationships between Substitution Pattern and ? Receptor Affinity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300302p

Posted on 17 May 2012 | 10:34 pm


Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase ? Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300403a

Posted on 17 May 2012 | 7:42 pm


Design, Synthesis, and Antiviral Evaluation of Purine-?-lactam and Purine-aminopropanol Hybrids

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300383k

Posted on 17 May 2012 | 7:41 pm


Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201485c

Posted on 17 May 2012 | 7:40 pm


New Synthetic Inhibitors of Fatty Acid Synthase with Anticancer Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm2016045

Posted on 16 May 2012 | 9:50 pm


Introducing the LASSO Graph for Compound Data Set Representation and Structure–Activity Relationship Analysis

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Journal of Medicinal Chemistry
DOI: 10.1021/jm3004762

Posted on 16 May 2012 | 8:44 pm


Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

Journal of Medicinal Chemistry
DOI: 10.1021/jm300288g

Posted on 11 May 2012 | 3:31 pm


Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of ?-Secretase (BACE1) through Fragment-Based Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201715d

Posted on 9 May 2012 | 5:50 pm


Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

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Journal of Medicinal Chemistry
DOI: 10.1021/jm300354j

Posted on 9 May 2012 | 6:02 am


Mitigating Heterocycle Metabolism in Drug Discovery

Journal of Medicinal Chemistry
DOI: 10.1021/jm300343m

Posted on 7 May 2012 | 7:46 pm


Selective Thyromimetics Using Receptor and Tissue Selectivity Approaches: Prospects for Dyslipidemia

Journal of Medicinal Chemistry
DOI: 10.1021/jm2004706

Posted on 1 May 2012 | 8:38 pm


Medicinal Chemistry of A3 Adenosine Receptor Modulators: Pharmacological Activities and Therapeutic Implications

Journal of Medicinal Chemistry
DOI: 10.1021/jm300087j

Posted on 17 April 2012 | 8:06 pm


Structural Modifications that Alter the P-Glycoprotein Efflux Properties of Compounds

Journal of Medicinal Chemistry
DOI: 10.1021/jm201136z

Posted on 16 April 2012 | 5:31 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
25.04.2011


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