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Journal of Medicinal Chemistry - Current Research Articles



Current research articles: Medicinal Chemistry

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Journal of Medicinal Chemistry - Editor: American Chemical Society, ACS

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.




Current articles of the journal:



5-Imino-1,2,4-Thiadiazoles: First Small Molecules As Substrate Competitive Inhibitors of Glycogen Synthase Kinase 3

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201463v

Posted on 3 February 2012 | 7:36 pm


Homobivalent Ligands of the Atypical Antipsychotic Clozapine: Design, Synthesis, and Pharmacological Evaluation

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201420s

Posted on 2 February 2012 | 8:23 pm


1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm2013216

Posted on 2 February 2012 | 3:52 pm


Trivalent Ultrashort Lipopeptides are Potent pH Dependent Antifungal Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm2014474

Posted on 1 February 2012 | 3:18 pm


Ligand-Based Design of a Potent and Selective Inhibitor of Cytochrome P450 2C19

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201346g

Posted on 31 January 2012 | 6:41 am


The 1.8 Å Crystal Structure of ACTIBIND Suggests a Mode of Action for T2 Ribonucleases As Antitumorigenic Agents

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Journal of Medicinal Chemistry
DOI: 10.1021/jm1015507

Posted on 31 January 2012 | 6:40 am


A Synthetic Chalcone as a Potent Inducer of Glutathione Biosynthesis

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Journal of Medicinal Chemistry
DOI: 10.1021/jm2016073

Posted on 30 January 2012 | 9:13 pm


Diverse Heterocyclic Scaffolds as Allosteric Inhibitors of AKT

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201394e

Posted on 27 January 2012 | 4:01 pm


Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201376w

Posted on 27 January 2012 | 3:59 pm


Molecular Determinants of AcrB-Mediated Bacterial Efflux Implications for Drug Discovery

Journal of Medicinal Chemistry
DOI: 10.1021/jm201275d

Posted on 27 January 2012 | 3:52 pm


Toll-Like Receptor (TLR)-7 and -8 Modulatory Activities of Dimeric Imidazoquinolines

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Journal of Medicinal Chemistry
DOI: 10.1021/jm2010207

Posted on 27 January 2012 | 3:50 pm


Exploring Activity Cliffs in Medicinal Chemistry

Journal of Medicinal Chemistry
DOI: 10.1021/jm201706b

Posted on 27 January 2012 | 6:57 am


Directed R-Group Combination Graph: A Methodology To Uncover Structure–Activity Relationship Patterns in a Series of Analogues

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201362h

Posted on 27 January 2012 | 6:56 am


Design and Characterization of Optimized Adenosine A2A/A1 Receptor Antagonists for the Treatment of Parkinson's Disease

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201640m

Posted on 26 January 2012 | 8:41 pm


Structure–Activity Relationship Study of Opiorphin, a Human Dual Ectopeptidase Inhibitor with Antinociceptive Properties

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Journal of Medicinal Chemistry
DOI: 10.1021/jm2012112

Posted on 25 January 2012 | 9:27 pm


A New Strategy for the Development of Highly Potent and Selective Plasmin Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm2011996

Posted on 25 January 2012 | 9:26 pm


The Bivalent Ligand Approach Leads to Highly Potent and Selective Acylguanidine-Type Histamine H2 Receptor Agonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201128q

Posted on 25 January 2012 | 7:36 pm


Structural Basis of Selective Inhibition of Human Tankyrases

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201510p

Posted on 25 January 2012 | 3:49 pm


Antimalarial Activity of 9a-N Substituted 15-Membered Azalides with Improved in Vitro and in Vivo Activity over Azithromycin

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201615t

Posted on 25 January 2012 | 1:35 pm


Design of Triazole-Stapled BCL9 ?-Helical Peptides to Target the ?-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201125d

Posted on 24 January 2012 | 5:43 pm


Design, Synthesis, and Biological Evaluation of New Diaminoquinazolines as ?-Catenin/Tcf4 Pathway Inhibitors

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201494a

Posted on 24 January 2012 | 5:36 pm


Drug-to-Genome-to-Drug, Step 2: Reversing Selectivity in a Series of Antiplasmodial Compounds

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201422e

Posted on 24 January 2012 | 1:56 pm


Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201533b

Posted on 24 January 2012 | 1:54 pm


Binding Evaluation of Fragment-Based Scaffolds for Probing Allosteric Enzymes

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201439b

Posted on 24 January 2012 | 1:54 pm


Impact of Lipophilic Efficiency on Compound Quality

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201388p

Posted on 24 January 2012 | 1:52 pm


Latent Hit Series Hidden in High-Throughput Screening Data

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Journal of Medicinal Chemistry
DOI: 10.1021/jm201328e

Posted on 23 January 2012 | 9:15 pm


Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

Journal of Medicinal Chemistry
DOI: 10.1021/jm201384j

Posted on 23 January 2012 | 1:20 pm


Avenues for the Development of Therapeutics That Target Trace Amine Associated Receptor 1 (TAAR1)

Journal of Medicinal Chemistry
DOI: 10.1021/jm201437t

Posted on 20 January 2012 | 1:52 pm


Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications

Journal of Medicinal Chemistry
DOI: 10.1021/jm201468j

Posted on 17 January 2012 | 4:16 pm


Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity

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Journal of Medicinal Chemistry
DOI: 10.1021/jm200720n

Posted on 13 January 2012 | 8:20 pm


Oxadiazoles in Medicinal Chemistry

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Journal of Medicinal Chemistry
DOI: 10.1021/jm2013248

Posted on 13 January 2012 | 5:54 pm


Rational Approaches to Improving Selectivity in Drug Design

Journal of Medicinal Chemistry
DOI: 10.1021/jm2010332

Posted on 12 January 2012 | 3:52 pm


Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal

Journal of Medicinal Chemistry
DOI: 10.1021/jm201095h

Posted on 21 December 2011 | 1:53 pm


Drug Discovery Research Targeting the CXC Chemokine Receptor 4 (CXCR4)

Journal of Medicinal Chemistry
DOI: 10.1021/jm200568c

Posted on 2 December 2011 | 4:00 pm





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Chronological list of recent articles on Chemistry, Medicinal Chemistry, Journal of Medicinal Chemistry.
Update:
25.04.2011


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