Nature Chemical Biology - Current Research Articles
Current research articles: Chemical Biology
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Nature Chemical Biology - Editor: Nature Publishing Group
'Nature Chemical Biology' is a monthly research journal of science that that publishes original research in three formats (Brief Communications, Letters and Articles), as well as News and Views, reviews, perspectives, commentaries, book reviews, meeting reports, research highlights and editorials covering all research at the interface of chemistry and biology.
Crk-like (CrkL) is a key signaling protein that mediates the leukemogenic activity of Bcr-Abl. Structural investigations show that the intramolecular assembly of CrkL is entirely distinct from that of CrkII, shedding light on how CrkL specifically mediates Bcr-Abl signaling.
Learning metabolism inevitably involves memorizing pathways. The teacher's challenge is to motivate memorization and to help students progress beyond it. To this end, students should be taught a few fundamental chemical reaction mechanisms and how these are repeatedly used to achieve pathway goals. Pathway knowledge should then be reinforced through quantitative problems that emphasize the relevance of metabolism to bioengineering and medicine.
Heterocycles such as thiazoles are introduced into ribosomally synthesized peptide metabolites by post-translational modification. The enzyme that installs those rings has been identified, providing insight into heterocyclization biochemistry and the potential capabilities of an entire protein family.
Renewed interest in the biological significance and applied outcomes of metabolism is moving the field from static biochemical charts to multidimensional networks.
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