Retrosynthesis

The retrosynthetic analysis.


Retrosynthesis or retrosynthetic analysis is a strategy for planning an organic synthesis by disconnecting a target molecule into precursor materials. This steps are repeated until available starting materials are reached.

The retrosynthetic analysis is not a synthesis form of organic chemistry, but an analytical approach based on the desired product. The target molecule is broken down into smaller and smaller fragments. The actual synthesis can then be designed based on the retrosynthetic analysis.

The method of retrosynthetic analysis is very effective, but it requires a great knowledge of chemical compounds, classes of compounds, chemical reactions, reaction conditions etc.

Below you will find online available information resources on retrosynthesis and retrosynthetic analysis.



Content:


Current Articles
Lecture Notes, Tutorials
Partial Information
Compounds



Current Articles


Aide de L'Ordinatuer en Synthese Organique
R. Barone, Cycle Chimie Fine, juin 2001 - [f]

Retrosynthesis Tutorial
... will allow you to practice retrosynthetic analysis using the target molecule below. You will find that there are several different ways to complete the retrosynthesis, depending on which strategies you choose. University of East Anglia, UK

Retrosynthetic Analysis
Analysis of Complex Synthetic Problems; Terminology; Retrosynthetic Strategies; Goals and Subgoals; Computer-Assisted Retrosynthetic Analysis. CMBI



Lecture Notes, Tutorials


Advanced Retrosynthesis
Lecture notes

Putting Reactions Together
Synthesis and Retrosynthesis. Arizona State University, USA - Format: PDF

Retrosynthesis
Definitions and terms - Format: PDF

Retrosynthesis
Notes and examples

Retrosynthesis
Lecture notes: designing organic syntheses. Universität Regensburg - Format: PDF

Retrosynthesis
Tutorial: Advanced Organic Chemistry - Format: PDF

Retrosynthesis Tutorial
Organic Synthesis and Carbon-Carbon Bond Forming Reactions

Retrosynthetic Analysis
Lecture notes - Format: PDF

Retrosynthetic Analysis
An introduction - Format: PDF

Retrosynthetic Analysis
An introduction - Format: PDF

Retrosynthetic Analysis
Examples - Format: PDF

Retrosynthetic Analysis
An introduction - Format: PDF

Strategies in Synthetic Planning
Modern Stylistic Points in Retrosynthetic Analysis - Format: PDF



Partial Information


Diels-Alder Retrosynthesis
Notes

Echinosporin
Retrosynthetic analysis of echinosporin - Format: PDF



Compounds


2-Methyl-1-propanol
. . . from 2-bromo-2-methylpropane - Format: PDF

Antillatoxin
Retrosynthetic Analysis of Antillatoxin - Format: PDF

Momilactone
Retrosynthetic analysis of Momilactone, Seychellene, Longifolene - Format: PDF

Monensin
Retrosynthetic analysis - Format: PDF

Tetrodotoxin
Survey of Tetrodotoxin Syntheses - Format: PDF




Related Books and Scientific Literature: Retrosynthesis


Book recommendation

Paul Wyatt, Stuart Warren

Organic Synthesis: Strategy and Control

Organic Synthesis: Strategy and Control is a sequel to Stuart Warren’s bestseller Organic Synthesis: The Disconnection Approach. The ‘Disconnection’ book concentrated on the planning behind the synthesis of compounds.

The two themes of this new book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work.

The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. Interpenetrating this structure, the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate mystery.

Wiley; 2007





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Entries: 24

Last update 24.08.2015

Keywords: Retrosynthesis, basics, information, theory, methods



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